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| 胶质细胞源性神经营养因子及其受体与疼痛 | |
| 引用本文： | 胡玉萍. 胶质细胞源性神经营养因子及其受体与疼痛[J]. 医学研究生学报, 2011, 24(2): 216-220 |
| 作者姓名： | 胡玉萍 |
| 作者单位： | 南京军区南京总医院麻醉科,南京,210002 |
| 基金项目： | 南京军区南京总医院科研基金(M2008048) |
| 摘 要： | 胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)是转化生长因子β(transforminggrowth fartor-β,TGF-β)超家族成员,具有多种重要的生物学活性,不仅特异性地促进多巴胺能神经元的存活,还对外周神经系统及非神经系统具有广泛的作用。文中就近年来对GDNF及其受体在神经系统中的作用,特别是痛觉调制中作用的国内外研究进展作一综述。 |
| 关 键 词： | 胶质细胞源性神经营养因子 胶质细胞源性神经营养因子家族受体α1 受体酪氨酸激酶 神经细胞黏附分子 神经痛 痛觉调制 |
Role of glial cell line-derived neurotrophic factor and its receptors in pain |
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| HU Yu-ping. Role of glial cell line-derived neurotrophic factor and its receptors in pain[J]. Bulletin of Medical Postgraduate, 2011, 24(2): 216-220 | |
| Authors: | HU Yu-ping |
| Affiliation: | HU Yu-ping reviewing,YANG Jian-jun,LI Wei-yan(Department of Anesthesiology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
| Abstract: | Glial cell line-derived neurotrophic factor belongs to the transforming growth factor-b(TGF-b) superfamily,which has many critical biologic-activity.GDNF is not only a survival factor for midbrain dopaminergic neurons specifically,but has an extensive role in peripheral nervous system and other parts.This article reviewed the role of glial cell line-derived neurotrophic factor and its receptors in nervous system,especially in modulating pain. |
| Keywords: | Glial cell line-derived neurotrophic factor Glial cell line-derived neurotrophic factor family receptor alpha 1 Receptor tyrosine kinase Neural cell adhesion molecule Neuropathic pain Pain modulation |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |