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| HERG钾离子通道与药物心脏毒性的安全性评价 | |
| 引用本文： | 郭舜. HERG钾离子通道与药物心脏毒性的安全性评价[J]. 医学综述, 2012, 18(16): 2572-2575 |
| 作者姓名： | 郭舜 |
| 作者单位： | 天津中医药大学,天津,300193 |
| 摘 要： | 人类ether-a-go-go相关基因(HERG)编码的快速延迟整流钾离子通道(Ikr)的α亚基介导的快速延迟整流钾电流在心肌动作电位复极过程中发挥着重要作用。HERG功能的缺失及药物抑制影响心脏动作电位复极过程,并会引起QT间期延长,同时可能诱发尖端扭转型室性心动过速,导致心律失常。HERG钾离子通道作为抗心律失常药物治疗的标靶,同时也越来越体现出在新药安全性检测和新药开发过程中的重要作用。 |
| 关 键 词： | HERG基因 QT间期延长 药物安全评价 |
HERG Potassium Ion Channels and Drug Cardiotoxicity Safety Evaluation |
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| GUO Shun. HERG Potassium Ion Channels and Drug Cardiotoxicity Safety Evaluation[J]. Medical Recapitulate, 2012, 18(16): 2572-2575 | |
| Authors: | GUO Shun |
| Affiliation: | 1.Tiangjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Tianjin Center for New Drug Safety Assessment,Tianjin 300301,China) |
| Abstract: | The human ether-a-go-go-related gene(HERG) encodes the pore-forming α-subunits of channels that conduct the rapid delayed rectifier K + current,which is one of the most important membrane currents responsible for ventricular action potential repolarization The absence of HERG function or drug inhibition results in a long QT interval,which may induce torsadestachycardia and lead to arrhythmia.The HERG potassium ion channels as anti-arrhythmic drug treatment target,hasmore and more displayed its important roles in new drugs safety test and development. |
| Keywords: | HERG gene QT interval prolongation Drug safety evaluation |
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