早产儿支气管肺发育不良与肺表面活性物质蛋白基因多态性的相关研究

随着早产儿存活率的不断提高,早产儿支气管肺发育不良(BPD)的问题日益突出。BPD需长时间用氧治疗,病死率高,存活者常遗留高反应性呼吸道疾病、反复下呼吸道感染、喂养困难、生长发育迟缓等问题,因此一直是新生儿重症监护室最为棘手的问题之一,也是严重影响早产儿生存质量的重要因素。近年来研究认为BPD的发病明显受基因和环境因素相互作用的影响。现就近年来有关早产儿BPD与肺表面活性物质蛋白基因多态性的相关研究进行综述。

The Study on Relationship between Premature Bronchopulmonary Dysplasia and Gene Polymorphism of Surfactant Protein

With the increasing survival rate of preterm children,the problems of preterm children bronchopulmonary dysplasia(BPD)are becoming prominent.The disease needs long-time oxygen and has high mortality.The survivals often have highly reactive airway disease,lower respiratory infection,feeding difficulties,and growth retardation,so it is one of the difficult problems in neonatal intensive care unit,which would be an important factor impacting on quality of life.Recent studies found that the incidence of BPD was significantly affected by complex interactions of genetic and environmental factors.Here is to make a review on the recent research of BPD and pulmonary surfactant protein gene polymorphism.