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| 甘糖酯对糖尿病大鼠肾小球基底膜阴离子位点的影响 | |
| 引用本文： | 张梅!应用基础医学研究所,陈飞,李才!应用基础医学研究所,邹雅斌!应用基础医学研究所,苗春生!应用基础医学研究所. 甘糖酯对糖尿病大鼠肾小球基底膜阴离子位点的影响[J]. 吉林大学学报(医学版), 1998, 0(5) |
| 作者姓名： | 张梅!应用基础医学研究所 陈飞 李才!应用基础医学研究所 邹雅斌!应用基础医学研究所 苗春生!应用基础医学研究所 |
| 作者单位： | 江苏如皋卫校 |
| 摘 要： | 目的 :观察甘糖酯对糖尿病大鼠尿蛋白排泄和肾小球基底膜阴离子位点的影响。方法 :糖尿病大鼠用甘糖酯处理 3周后 ,肾皮质小块浸泡于多聚亚胺溶液 ,用电子显微镜定量研究基底膜阴离子位点。结果 :与对照组大鼠相比 ,糖尿病大鼠尿蛋白排泄量明显增加 ,肾小球基底膜阴离子位点明显减少 ;甘糖酯处理使糖尿病大鼠尿蛋白排泄量显著减少 ,使基底膜阴离子位点明显增加。结论 :甘糖酯能明显改善糖尿病大鼠肾小球电荷屏障功能 ,降低肾小球毛细血管壁的通透性 |
| 关 键 词： | 甘糖酯 肾小球基底膜 阴离子位点 糖尿病 |
Effect of PGMS on anionic sites in glomerular basement membrane in diabetic rats |
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| Zhang Mei ,Chen Fei ,Li Cai ,Zou Yabin ,Miao Chunsheng. Effect of PGMS on anionic sites in glomerular basement membrane in diabetic rats[J]. Journal of Jilin University: Med Ed, 1998, 0(5) | |
| Authors: | Zhang Mei Chen Fei Li Cai Zou Yabin Miao Chunsheng |
| Affiliation: | 1 Institute of Preclinical Sciences;2 Rugao Health School of Jiangsu province |
| Abstract: | Objective:To study the effect of proglylene glucol mannate sulfate (PGMS) on urinary protein excretion and anionic sites in glomerular basement membrane (GBM) in streptozotocin induced diabetic rats.Methods:After induction of diabetes,the rats were treated with PGMS (100 mg/kg·day) for 3 weeks.The pieces of renal cortex were immersed in polyethyleneimine solution and anionic sites in GBM were quantitatively evaluated by electron microscope.Results:Urinary protein excretion markedly increased and anionic sites in GBM significantly decreased in diabetic rats,compared with control animals.In PGMS treated diabetic rats,urinary protein excretion decreased and anionic sites in GBM obviously increased.Conclusion:PGMS can improve glomerular charge barrier and reduce permeability of glomerular capillary wall. |
| Keywords: | proglylene glucol mannate sulfate (OGMS) glomerular basement membrane anionic site diabetes |
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