狂息宁合并碳酸锂治疗躁狂发作的对照研究

目的：探讨自制中药汤剂狂息宁合并碳酸锂治疗躁狂发作的疗效及安全性。方法：将120例躁狂发作患者随机分为狂息宁合并碳酸锂（研究组）和单用碳酸锂（对照组）各60例,观察治疗6周,采用躁狂量表（BRMS）、副反应量表（TESS）评定疗效和副反应并进行对比。结果：治疗后的第2、4、6周末,研究组、对照组BRMS评分均较治疗前下降,差异有统计学意义（P〈0.05或P〈0.01）。研究组在第1、2周末减分较对照组差异有显著性意义（P〈0.05）,两组在第6周末减分差异无显著性意义（P〉0.05）;研究组副反应发生率较低,且程度较轻,患者耐受性好。结论：狂息宁合并碳酸锂治疗躁狂发作起效快、疗效肯定、副反应较轻、安全性及依从性好,值得临床推广应用。

A control study of Kuangxining combined with lithium carbonate in the treatment of manic episode

Objective：To evaluate the efficacy and safety of Kuangxining combined with lithium carbonate in the treatment of manic episode. Methods ：120 patients with manic episode were randomly divided into study group （n = 60, Kuangxining combined with lithium carbonate） and control group （n = 60, lithium carbonate） , treatment for 6 weeks. Using BRMS and the TESS to assess the efficacy and adverse reactions, and compared. Results： After treatment of 2,4,6 week ,two groups of BRMS scores were decreased than that before treatment ,there were statistical differences（ P 〈 0.05 or P 〈 0.01 ）. The less points of study group was significant compared with control group at the 1st ,2nd weekend （P 〈 0.05 ） ;the minus points difference oftwo groups at the 6th weekend was not statistically significant（ P 〈 0.05 ）. The side reaction of research group is lower, and the patients are more likely to accept. Conclusion ： Kuangxining combined with lithium carbonate has fast onset, more effective,less adverse reactions, safety and compliance, and it is worthy of clinical application.