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| 亚硒酸钠对SGC－7901细胞内环核苷酸累积的影响 | |
| 引用本文： | 叶庆林,林硕,郑辉,洪秀维,杨俐丽,林爱珍. 亚硒酸钠对SGC－7901细胞内环核苷酸累积的影响[J]. 福建医科大学学报, 1994, 0(4) |
| 作者姓名： | 叶庆林 林硕 郑辉 洪秀维 杨俐丽 林爱珍 |
| 作者单位： | 福建医学院生物化学教研室 |
| 摘 要： | 研究亚硒酸钠对胃癌细胞株ＳＧＣ－７９０１细胞的生长增殖和细胞内环核苷酸累积的影响，结果表明亚硒酸钠显著抑制ＳＧＣ－７９０１细胞的生长增殖，对静息的和肾上腺素刺激的ｃＡＭＰ累积均无显著影响，但可使ｃＧＭＰ累积显著减少，ｃＡＭＰ／ｃＧＭＰ比值升高，提示亚硒酸钠对肿瘤细胞的抑制作用可能与减少ｃＧＭＰ的合成有关。 |
| 关 键 词： | 亚硒酸钠，cAMP累积，cGMP累积，胃癌细胞 |
Effect of Sodium Selenite on Intracellular Cyclic Nucleotide Accumulation in SGC-7901 Cells |
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| Ye Qinglin,Lin Shuo,Zheng Hui,et al. Effect of Sodium Selenite on Intracellular Cyclic Nucleotide Accumulation in SGC-7901 Cells[J]. Journal of Fujian Medical University, 1994, 0(4) | |
| Authors: | Ye Qinglin Lin Shuo Zheng Hui et al |
| Abstract: | A study of the effects of soditim selenite on human stomach cancer cell line(SGC-7901cells)was carried out.The results showed that 10-5 mol/L sodium selenite remarkably inhibited the growth and proliferation of the cells,accompanied by cGMP decreased,but did not influence the basal cAMP and adrenalin (10-5mol/L)stimulated cAMP accumulation,The results suggested that the effect of soditim selenite was probably due to its effect of decreasing the cGMP synthetsis. |
| Keywords: | sodium selenite cAMP accumtilation cGMP accumulation stomach cancer cells |
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