EARLY AGALACTOSYLATION OF IgG IS ASSOCIATED WITH A MORE PROGRESSIVE DISEASE COURSE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A FOLLOW-UP STUDY |
| |
| Authors: | VAN ZEBEN, D. ROOK, G. A. W. HAZES, J. M. W. ZWINDERMAN, A. H. ZHANG, Y. GHELANI, S. RADEMACHER, T. W. BREEDVELD, F. C. |
| |
| Affiliation: | *Departments of Rheumatology Leiden, The Netherlands
!["{dagger}"]("/math/dagger.gif") Department of Medical Microbiology, School of Pathology, University College and Middlesex School of Medicine London
!["{ddagger}"]("/math/Dagger.gif") Departments of Medical Statistics University Hospital Leiden, The Netherlands
!["§"]("/math/sect.gif") Glycobiology Unit, Department of Biochemistry, University of Oxford Oxford |
| |
| Abstract: | ![]()
The clinical significance of the percentage agalactosyl IgGoligosaccharides [%G(O)] was investigated in serum of a well-characterizedcohort of 127 female RA patients who were followed for a meanduration of 6 yr. The %G(O) was determined in the first availableserum sample which was obtained at a mean of 3.4 yr after symptomonset. It could be shown that patients with a %G(O) more than2 S.D. above the mean level of controls (n = 34), had significantlymore erosions, disease activity, and were treated with moresecond-line drugs, than patients without an increased %G(O)(n = 93), both at the time the serum sample was obtained, andduring follow-up. These findings suggest that G(O) may serveas an indicator for the disease course in patients with RA. KEY WORDS: Agalactosyl IgG, Prognosis, Outcome |
| |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ |
|
