食管鳞癌组织中骨桥蛋白的表达及其临床意义

目的 研究骨桥蛋白（osteopontin,OPN）在食管鳞癌患者组织中的表达及临床意义。方法 分别选取120例食管鳞癌癌组织、46例癌旁不典型增生组织和120例正常食管黏膜组织,分别用免疫组化法检测各种组织中OPN蛋白的表达情况,并分析其临床意义。结果 在食管鳞癌癌组织、癌旁不典型增生组织和正常食管黏膜组织中,OPN的阳性表达率分别为76.67%（92/120）、34.78%（16/46）和0（0/120）。食管鳞癌的临床分期、淋巴结转移、癌组织的浸润深度均与OPN蛋白的阳性表达明显相关（P均〈0.05）。食管鳞癌组织中OPN蛋白阳性表达组与阴性表达组患者的5年生存率分别为10.7%及28.6%（P〈0.05）。结论 OPN蛋白在食管鳞癌的发生、发展中起到十分重要的作用,检测OPN蛋白的表达具有重要临床意义。

Expression and clinical significance of osteopontin in esophageal squamous carcinoma

Objective To analyze the expression and clinical significance of osteopontin（OPN） in esophageal carcinoma. Methods Immunohistochemistry was used to detect the expression of OPN in normal esophageal tissue and in 120 specimens of esophageal carcinoma tumor tissue and tumor-adjacent tissue showing atypical hyperplasia. Results OPN expression density was lowest in normal esophageal tissues （0）,higher in tumor-adjacent tissues showing atypical hyperplasia（34.78%） and highest in esophageal carcinoma tissues （76.67%）. Expression of OPN protein correlated with tumor TNM stage,lymph node metastasis and infiltrative depth of esophageal squamous cell carcinoma （P〈0.05）. The five-year survival rate was significantly higher in patients negative for OPN expression than in those positive for OPN expression （28.6% vs 10.7%, P〈0.05 ）. Conclusion Studying OPN expression may generate insights into the pathogenesis, invasion and metastasis of esophageal carcinoma, and it may provide tools for predicting the prognosis of patients with the disease.