低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价

目的:探讨低剂量普萘洛尔联合1 064 nmNd:YAG激光治疗混合型和深层婴儿血管瘤(IH)的疗效和安全性。方法:60例混合型和深层IH患儿,按照随机数字表分为普萘洛尔组、激光组和普萘洛尔联合激光组,每组20例。普萘洛尔联合激光组患儿采用普萘洛尔1.5 mg·kg^-1·d^-1联合激光治疗,普萘洛尔组患儿采用普萘洛尔1.5 mg·kg^-1·d^-1,激光组患儿单纯采用激光治疗,比较3组患者治疗6个月后的总有效率、显效率、痊愈率和不良反应程度评分。结果: 治疗6个月后,普萘洛尔联合激光组患儿总有效率、显效率和痊愈率高于激光组和普萘洛尔组(P<0.05),普萘洛尔联合激光组皮肤不良反应程度评分低于激光组和普萘洛尔组(P<0.05)。结论:低剂量普萘洛尔联合1 064 nmNd:YAG激光是治疗混合型和深层IH的一种安全有效的方法,具有疗效好、疗程短和不良反应少的优势。

Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma

Objective To explore the efficacy and safty of low dose propranolol with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma(IH). Methods 60 patients with mixed and deeper IH were randomly divided into propranolol group(n=20,the patients were treated by 1.5 mg·kg-1·d^-1 propranolol),laser group(n=20,the patients were treated by 1 064 nm Nd:YAG laser), and propranolol combined with laser group(n=20,the patients were treated by 1.5 mg·kg^-1·d^-1 propranolol and 1 064 nm Nd:YAG laser).After 6 months,the total efficacy rate, efficacy rate and cure rate,and the scores of adverse event degrees were compared respectively. Results 6 months later,the total efficacy rate,efficacy rate and cure rate of the patients in propranolol combined with laser group were higher than those in laser group and propranolol group(P<0.05);the scores of adverse event degrees in body surface of the patients in propranolol combined with laser group were lower than those in laser group and propranolol group(P<0.05). Conclusion Low dose of propranolol combined with 1 064 nm Nd:YAG laser is effective and safe for the patients with mixed and deeper IH,with the advantages such as better effects,shorter duration and fewer adverse events.