新疆一枝蒿提取物保肝作用的实验研究

目的：探讨新疆一枝蒿提取物（ARE）对化学性肝损伤及免疫性肝炎的保护和治疗作用。方法：采用卡介苗（BCG）加脂多糖（LPS）引起的小鼠免疫性肝炎模型及四氯化碳和D－氢基半乳糖致小鼠、大鼠急性肝损伤模型，观察ARE对免疫性肝炎的预防和治疗作用及对化学性肝损伤的保护作用。结果：ARE大剂量能明显降低免疫性肝炎小鼠血清谷丙转氨酶（ALT）水平（P＜0．05），ARE各种剂量皆能降低四氯化碳致肝损伤小鼠和大鼠血清ALT（P＜0．01），降低D－氨基半乳糖致肝损伤小鼠血清ALT（P＜0．05）。结论：ARE具有明显的保护化学性肝损伤及治疗免疫性肝炎的功能，但对免疫性肝炎无预防作用。

Experimental Study on Liver Protective Effect of Artemisia Rupestris Ex tract

To explore the protective effect of Artemisia rupestris extract (ARE) on chemical liver injury and immunological hepatitis. Methods: Mice model of immunological hepatitis was established by lipopolysacc haride plus Bacillus Calmette Guérin vaccine (BCG), and the mo dels of liver injury was induced by D galactosamine or carbon tetrachloride (CC l 4) in mice and rats. The effects of ARE in preventing and treating immunologi cal hepatitis and protecting liver injury were observed. Results: ARE significantly lowered the serum alanine transamin ase (ALT) in immunonological hepatitis (P<0 05), CCl 4 induce d liver injury model mice and rats (P<0 01), and in D galacto samine induced liver injury mice (P<0 05). Conclusion: ARE has significantly protective effect against ch emical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.