天然多酚衍生物抗肿瘤侵袭与转移研究进展

肿瘤侵袭与转移是恶性肿瘤的基本特征,是临床肿瘤患者死亡的最主要原因。肿瘤侵袭与转移过程涉及细胞的脱落、浸润、迁移运行、着床、新生血管生成等过程,作用机制非常复杂,因此,防止肿瘤转移一直是肿瘤治疗的难题。近年来研究发现,许多天然产物具有抗肿瘤侵袭和转移能力,该文对天然多酚类化合物的抗肿瘤侵袭和转移作用的研究进展进行综述。

Progress on natural polyphenols as anti-invasive and anti-metastasis agents

The ability to invade and metastasize is a hallmark of malignant tumors, and metastasis poses the biggest problem to cancer treatment and is the main cause of death of cancer patients. Tumor invasion and metastasis are complex, multistep biochemical process, which involve cell detachment, invasion, migration, intravasation and circulation, implantation, angiogenesis and proliferation. Therefore, how to prevent tumor metastasis are the biggest challenge in cancer chemotherapy. In recent years, many natural products are found to have anti-invasion and anti-metastasis activities. In this paper, the natural polyphenolic compounds are classified according to their chemical structures, including diarylheptanoids, stibenoids, flavonoids, phenylpropanoids, cannabinoids and naphthoquinones, and their anti-invasion and anti-metastasis activities and biological targets are introduced.