Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro

Forty-two compounds belonging to various chemical groups havebeen tested for their ability to suppress formation of aflatoxinB₁-DNA adduct mediated by microsome in vitro. While many ofthese compounds have either marginal or no modulating effect,some have been identified as effective inhibitors. The stronginhibition of DNA adduct formation by retinoids (retinol, retinal,retinoic acid and retinyl acetate), riboflavin, riboflavin 5'-phosphate,flavin adenine dinudeotide, Cu²⁺, 7,8-benzoflavone, disulfiram,butylated hydroxyanisole, butylated hydroxytoluene and phenothiazinesuggests that these agents may have potential anticardnogenicactivity against aflatoxin B₁.