胃泌素在胃炎与胃癌中表达的差异及意义

目的探讨胃炎与胃癌中,胃体、胃窦组织内胃泌素表达的水平的差异与意义。方法收集我院2009～2010年胃癌手术患者21例,选取同期行胃镜检查的慢性浅表性胃炎患者20例作为对照,免疫组化法检测组织内胃泌素的表达,IPP软件测定胃泌素累积光密度。结果不同性别及不同年龄胃泌素累积光密度的对数差异无显著性（P值分别为0.151和0.482）。胃炎组胃泌素累积光密度对数的中位数在胃体为2.58（1.60～4.24）,胃窦为4.55（3.27～5.23）（Z=4.166,P=0.000）;癌组织与癌旁组织比较,胃体处癌为1.46（0.00～4.61）,癌旁为3.51（0.00～5.30）（Z=3.089,P=0.002）,胃窦处癌为0.00（0.00～4.23）,癌旁为4.89（4.26～5.55）（Z=4.916,P=0.000）;癌旁组织与胃炎组相应部位比较,胃体处癌旁为3.51（0.00～5.30）,胃炎组为2.58（1.60～4.24）（Z=2.397,P=0.017）,胃窦处癌旁为4.89（4.26～5.55）,胃炎组为4.55（3.27～5.23）（Z=2.193,P=0.028）;癌与胃炎组比较,胃体处癌为1.46（0.00～4.61）,胃炎组为2.58（1.60～4.24）（Z=2.578,P=0.010）,胃窦处癌为0.00（0.00～4.23）,胃炎组为4.55（3.27～5.23）（Z=4.828,P=0.000）。结论不同性别及不同年龄胃泌素表达差异无显著性。胃泌素在胃窦处表达高于胃体。无论胃体胃窦,癌旁、胃炎、癌组织中胃泌素表达呈递减趋势。胃泌素表达水平的变化可能为胃癌发生前的一种状态。

Difference between Benign and Malignant Gastric Diseases in the Level of Gastrin

Objective To explore the relationship between gastrin and the development of gastric cancer by comparing gastrin level between benign and malignant gastric diseases at different locations. Methods During 2009-2010,21 patients with gastric cancer and 20 patients with gastritis who received operation or endoscopic examination in our hospital were enrolled in this study.The gastrin level in the lesions was determined by measuring cumulated IOD using IPP software after immunohistological staining.ResultsNo sign...