脑卒中后抑郁对神经功能康复及生活质量的影响

目的:探讨脑卒中后抑郁对神经功能康复及生活质量的影响,并应用盐酸帕罗西汀(赛乐特)进行抗抑郁治疗。方法:68例脑卒中后抑郁患者随机分为观察组和对照组各34例,均给予系统的康复治疗,观察组患者同时每天口服赛乐特20 mg抗抑郁治疗,对照组口服维生素B1;治疗前后分别采用Zung抑郁状态自评量表、Fugl-Meyer、Barthel指数及生活满意指数A(LSIA)对患者进行评定。结果:治疗6周后抑郁评分,观察组(55.3±13.3)与治疗前(70.6±14.2)及对照组(63.8±13.9)比较显著降低(P<0.01,P<0.05);Fugl-Meyer、Barthel指数及LSIA评分,治疗后2组均有提高,观察组更显著(P<0.01)。结论:改善脑卒中后抑郁状态有利于神经功能康复及生活质量的提高。

Effects of Post-stroke Depression on the Recovery of Neurological Function and the Quality of Life

Objective:To explore the effects of poststroke depression on the recovery of neurological function and the quality of life and the effectiveness of seraxat in treatment of depression.Methods: Eighty-six post-stroke depression cases were randomly divided into observation group(n=34) and control group(n=34),and they were all subjected to rehabilition therapy,at the same time the patients in the observation group accepted anti-depresssive therapy.All of cases were evaluated according to Self-Rating Depression Scale(SDS),Fugl-Meyer Motor Assessment,ADL and life satisfaction index A before and after treatment.Results: after treatment the scores of SDS in observation group were lower after treatment than before treatment(P<0.01) and those in control group(P<0.01).The scores of Fugl-Meyer,ADL and LSIA in observation group were higher than those in control group(P<0.01).Conclusion: Anti-depresssive therapy may be helpful to rehabilitate neurological function and improve the quality of life.