不同诱发电位评价猴实验性变态反应性脑脊髓炎的价值

目的探讨不同诱发电位评价猴实验性变态反应性脑脊髓炎(experimental allergic encephalomyelitis, EAE)的价值. 方法选择 5年前制作的 8只EAE猴为实验组,另选 13正常猴作对照组,分别进行脑干听觉诱发电位(brainstem auditory evoked potential, BAEP)、脑干三叉神经诱发电位 (brainstemtrigeminal evoked potential, BTEP)、体感诱发电位 (somatosensory evoked potential,SEP)检测. 结果 EAE猴 BAEP的Ⅲ-Ⅴ峰间期为 (3.0± 0.63)ms, BTEP的 T1-T7、T3-T7峰间期为 (2.53± 0.67)、 (1.68± 0.37)ms, SEP的 P40-N21峰间期为 (13.38±3.61)ms, BAEP、 BTEP及 SEP各波峰间期与对照组相比明显延长. BAEP、 BTEP、BAEP+ BTEP及下肢 SEP检查 EAE猴异常率分别是 50%, 50 %, 62%及 81%. 结论BAEP, BTEP, SEP都可以检出 EAE猴中枢神经系统的损害,其中下肢 SEP阳性率最高,BAEP和 BTEP联合检查可使阳性率增高.

Significance of different evoked potentials in evaluation of experimental allergic encephalomyelitis in monkeys

AIM:To explore the significance of evoked potentials in the evaluation of experimental allergic encephalomyelitis(EAE) in monkeys. METHODS:Eight monkey models of EAE established 5 years ago were used as the experimental animal group and another 13 normal monkeys as the control group.Evoked potentials including brainstem auditory evoked potential(BAEP),brainstem trigeminal evoked potential(BTEP) and somatosensory evoked potential(SEP) were respectively examined in these monkeys. RESULTS:The interpeak latency Ⅲ-Ⅴ of BAEP(3.0± 0.63) ms,T1-T7 and T3-T7 interpeak latencies of BTEP(2.53± 0.67) and(1.68± 0.37) ms, and P40-N20 interpeak latency of SEP(13.38± 3.61) ms were significantly prolonged in EAE group as compared with the control group(P< 0.05).The abnormality rate of BAEP, BTEP,BAEP plus BTEP,and SEP of the lower limbs were 50% ,50% ,62% ,and 81% respectively in EAE group. CONCLUSION:BAEP,BTEP and SEP are all indicative of the damages of the central nervous system in monkeys with EAE.SEP of lower limbs is the most sensitive to detect the abnormality,and the examination of BAEP in conjunction with BTEP may increase the detection rate.