抗惊厥药致药物超敏综合征20例临床特征分析

目的探讨抗惊厥药所致药物超敏综合征（DHS）的临床特征。方法回顾分析20例抗惊厥药所致DHS患者的临床表现、实验室检查、治疗方法、并发症及预后。结果抗惊厥药所致DHS潜伏期长,皮损形态多样,以发疹型为主,常伴有紫癫样斑疹、皮肤肿胀及反复脱屑,多有发热、黏膜损害、浅表淋巴结增大及血常规异常。脏器多受累以肝脏为主、肾脏次之。糖皮质激素治疗有效。结论DHS为具有特征性表现的临床综合征,病程较长,早期、尽量地应用糖皮质激素有助于预后的改善。

Clinical Study of 20 Patients with Drug Hypersensitivity Syndrome by Anticonvulsant

Objective:To investigate the anticonvulsantDrug-induced drug hypersensitivity syndrome(DHS),the clinical features.Methods:Retrospective analysis of 20 cases of pati ents with ant iconvulsant,complications and prognosis.Results:anticonvulsant drug-induced latency DHS plant lesions varied shapes,with a measl es-type,often accompanied by a kind spotted purpura.repeatedly scaling skin swelling and more have a fever and mucosal lesions,superficial Lymph node enlargement and the blood system.Multi-organ involvement mainly in the liver,kidn eytimes.Glucocorticoid therapy.Conclusion:DHS for the performance of charactreristic clinical syndrome,saying longer,in the early days,glucocorticoids foot lot s quarter from 200030 to improve e the prognosis.