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Cytotoxicity of cyclophosphamide and acrylamide in glioma and neuroblastoma cell lines cocultured with liver cells |
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| Authors: | Ann-Charlotte Ericsson Erik Walum |
| Affiliation: | Department of Neurochemistry and Neurotoxicology, University of Stockholm, Enköpingsvägen 126, S-172 46, Sundbyberg, Sweden |
| Abstract: | A method for the cocultivation of nervous system cells with liver cells has been developed. When acrylamide was tested using the cocultivation procedure no significant liver metabolism-mediated changes in the cytotoxicity in C6 culture were detected. In neuroblastoma NIE115 cultures the toxicity was increased by induced chick hepatocytes at high acrylamide concentrations. |
| Keywords: | Neuroblastoma cells glioma cells liver cells, cyclophosphamide acrylamide liver metabolism roller incubation |
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