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Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus
Authors:Mana Ichimura  Koichi Hiratsuka  Naomi Ogura  Tadahiko Utsunomiya  Hiroyuki Sakamaki  Toshirou Kondoh  Yoshimitsu Abiko  Shigeo Otake  Masafumi Yamamoto
Affiliation:Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Abstract:BACKGROUND: To understand the immunopathological features of oral lichen planus (OLP), we analyzed the expression of chemokines in the epithelial cell layers. Methods: Epithelia from OLP or healthy gingiva were collected by laser microdissection. The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray. RESULTS: High levels of MIP-3alpha/LARC/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC-CK1/CCL18, ELC/CCL19, SDF-1/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11) and CCR5 (e.g. RANTES/CCL5). CONCLUSIONS: Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5.
Keywords:chemokine    chemokine receptor    DNA microarray    epithelial cell layer    oral lichen planus
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