|
|||||
|
|
| 血府逐瘀颗粒对急性心肌梗死犬的保护作用 | |
| 引用本文： | 王秋静,崔新明,吕文伟,路航,崔璐. 血府逐瘀颗粒对急性心肌梗死犬的保护作用[J]. 中国现代医学杂志, 2006, 16(15): 2287-2289,2293 |
| 作者姓名： | 王秋静 崔新明 吕文伟 路航 崔璐 |
| 作者单位： | 1. 吉林大学新民校区基础医学院,吉林,长春,130021 2. 吉林大学化学院教学中心,吉林,长春,130021 3. 吉林大学生物与农业工程学院,吉林,长春,130025 |
| 摘 要： | 目的观察血府逐瘀颗粒对急性心肌梗死犬的保护作用。方法将24只杂种犬。随机分为4组。第1组为生理盐水（Control）对照组。第2组为阳性药血府逐瘀口服液（xfzhyo）对照组。第3。4组为血府逐瘀颗粒（xfzhyg）小，大剂量组。采用麻醉开胸犬。结扎冠状动脉左前降支。复制犬急性心肌梗死模型。测定心肌梗死面积（MIS）、血清心肌三酶以及心肌细胞超微结构的改变。结果血府逐瘀颗粒均可缩小MIS，降低心肌三酶的活性。减轻缺血对心肌细胞超微结构的损伤程度。结论血府逐瘀颗粒对急性心肌梗死犬的心肌具有一定的保护作用。 |
| 关 键 词： | 血府逐瘀颗粒 心肌梗死 心肌酶 超微结构 |
| 文章编号： | 1005-8982（2006）15-2287-03 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2005-10-21 |
Protective effect of xfzhyg on myocardium in dogs with experimental myocardial infarction |
|
| WANG Qiu-jing,CUI Xin-ming,LV Wen-wei,LU Hang,CUI Lu. Protective effect of xfzhyg on myocardium in dogs with experimental myocardial infarction[J]. China Journal of Modern Medicine, 2006, 16(15): 2287-2289,2293 | |
| Authors: | WANG Qiu-jing CUI Xin-ming LV Wen-wei LU Hang CUI Lu |
| Affiliation: | 1. School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R.China; 2.Teaching center of Shool of Chemistry, JilinUniversity, Changchun, Jilin 130021, P.R.China; 3.College of Biology and Agriculature Engineering, Jilin University, Changchun, Jilin 130025, P.R.China |
| Abstract: | [Objective] To observe the protective effects of xfzhyg on acute myocardial infarction in dogs. [Methods] Twenty-four dogs were devided at random into four groups: control group; xfzhyo group; low-dose xfzhyg group; high-dose xfzhyg group. The myocardial infarction size, the changes of myocardial enzymes(AST,CPK,LDH) and the changes of the myocardial ultrastructure were determined by using the acute myocardial infarction models of ligation of left anterior descending branch (LAD) in the anaesthetized open-chest dogs. [Results] The myocardial infarction size, the activity of blood serum AST, CPK, LDH and the ultrastructral injuries were decreased in acute myocardial infarction dogs treated with xfzhyg. [Conclusions] Xfzhyg has the protective effects on acute myocardial infarction in dogs. |
| Keywords: | xfzhyg myocardial infarction myocardium enzyme ultrastructure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |