| Imperatorin Is Responsible for the Vasodilatation Activity of Angelica Dahurica var. Formosana Regulated by Nitric Oxide in an Endothelium-Dependent Manner |
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| 作者姓名： | 聂红 孟兰贞 周玖瑶 樊晓峰 Yong Luo- 张广文 |
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| 作者单位： | College of Pharmacy Jinan University Guangzhou University of Chinese Medicine Research Center for Analytical Sciences of Northeastern University College of Science and Engineering |
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| 基金项目： | Supported by the National Natural Science Foundation of China (No.30400596);; Jinan University Natural Science Foundation (No.51204017);; 211 Project of Jinan University |
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| 摘 要： | Objective:To demonstrate the vasodilatation activity of the coumarin-containing Angelica dahurica var.formosana and to further analyze active components in the herb extracts.Methods:(1) The vasodilatation effects induced by different extracts(cyclohexane,ethyl acetate,acetone,methanol,95%ethanol and water) of Angelica dahurica var.formosana on mouse thoracic aorta pre-contracted with phenylephrine were investigated. (2) The amount of imperatorin and isoimperatorin in each extract was measured by high-per...
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| 关 键 词： | Angelica dahurica var.formosana thoracic aorta vasodilatation imperatorin isoimperatorin high-performance liquid chromatography |
| 收稿时间： | 28 June 2007 |
Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner |
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| Authors: | Hong Nie Lan-zhen Meng Jiu-yao Zhou Xiao-feng Fan Yong Luo- and Guang-wen Zhang |
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| Institution: | (1) Jiangsu Center for Research & Development of Medicinal Plants, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Mem. Sun Yat-Sen., Nanjing, 210014, PR China; |
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| Abstract: | Objective To demonstrate the vasodilatation activity of the coumarin-containing Angelica dahurica var. formosana and to further analyze active components in the herb extracts. |
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