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| 脂/水分配预测10-羟基喜树碱在大鼠小肠中的吸收 | |
| 引用本文： | 索绪斌,李慕玲,王玉强,朱盛山. 脂/水分配预测10-羟基喜树碱在大鼠小肠中的吸收[J]. 中国中药杂志, 2010, 35(3): 378-380 |
| 作者姓名： | 索绪斌 李慕玲 王玉强 朱盛山 |
| 作者单位： | 1. 广东药学院,中药开发研究所,广东,广州,510006;暨南大学药学院,广东,广州,510632 2. 暨南大学药学院,广东,广州,510632 3. 广东药学院,中药开发研究所,广东,广州,510006 |
| 基金项目： | 广东药学院"重点培养青年教师"基金项目(200809052) |
| 摘 要： | 目的:探讨脂质体/水(脂/水)相中的分配,预测10-羟基喜树碱(HCPT)在大鼠小肠中吸收的可行性.方法:采取在体小肠吸收模型,研究不同pH条件下HCPT在大鼠小肠中的吸收;采取平衡透析法检测不同pH条件下药物在脂质体/水相中分配系数;探讨HCPT在脂质体/水相中分配与药物的在体吸收的相关性.结果:HCPT在脂质体/水相中的分配及在体小肠吸收随外界环境pH的不同而改变,两者相关性良好.结论:用脂质体/水相中的分配可以预测HCPT在大鼠小肠中的吸收. |
| 关 键 词： | 10-羟基喜树碱 脂质体/水相 小肠吸收 |
| 收稿时间： | 2009-04-20 |
Prediction of absorption of 10-hydroxycamptothecin in small intestinesof rats with its partition coefficients in phases of liposomes and water |
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| SUO Xubin,LI Muling,WANG Yuqiang and ZHU Shengshan. Prediction of absorption of 10-hydroxycamptothecin in small intestinesof rats with its partition coefficients in phases of liposomes and water[J]. China Journal of Chinese Materia Medica, 2010, 35(3): 378-380 | |
| Authors: | SUO Xubin LI Muling WANG Yuqiang ZHU Shengshan |
| Affiliation: | Research and Development Institute of Traditional Chinese Materia Medica,Guangdong PharmaceuticalUniversity, Guangzhou 510006, China;School of Pharmacy, Jinan University, Guangzhou 510632, China;School of Pharmacy, Jinan University, Guangzhou 510632, China;School of Pharmacy, Jinan University, Guangzhou 510632, China;Research and Development Institute of Traditional Chinese Materia Medica,Guangdong PharmaceuticalUniversity, Guangzhou 510006, China |
| Abstract: | This paper explore the possibility of using the partition of 10-hydroxycamptothecin in the phases of liposome and water to predict the absorption of the drug in small intestine of rats. In order to certify this theory, the in vivo absorption model have been used to study the absorption of 10-hydroxycamptothecin in the small intestine of rats while altering the pH of the medium. The correlation has been explored between the partition of drug in the phases of liposome and water and the absorption of drug in the small intestines of rats. And it was found that the partition of 10-hydroxycamptothecin in the phases of liposome and water and the absorption of the drug in small intestines of rats altered with the changes of pH, and there existed a good relative coefficient between them. All of these indicated that partition of 10-hydroxycamptothecin in phases of liposome and water can be used to predict its absorption in small intestines of rats. |
| Keywords: | 10-hydroxycamptothecin phases of liposome/water absorption in small intestines |
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