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| 炎症小体与中枢神经系统疾病 | |
| 引用本文： | 杜秀明,张子腾,宗英,余琛琳,张晓冬,陆国才. 炎症小体与中枢神经系统疾病[J]. 药学实践杂志, 2016, 34(1): 12-15 |
| 作者姓名： | 杜秀明 张子腾 宗英 余琛琳 张晓冬 陆国才 |
| 作者单位： | 第二军医大学卫生毒理学教研室, 上海 200433,第二军医大学卫生毒理学教研室, 上海 200433,第二军医大学卫生毒理学教研室, 上海 200433,第二军医大学卫生毒理学教研室, 上海 200433,第二军医大学卫生毒理学教研室, 上海 200433,第二军医大学卫生毒理学教研室, 上海 200433 |
| 基金项目： | "重大新药创制"科技重大专项(2014ZX09J14106);国家自然科学基金(81473291、81402651);上海市自然科学基金(13ZR144940);上海市公共卫生重点实验室建设计划(12GWZX0501) |
| 摘 要： | 炎症小体是一蛋白复合物,能够识别不同刺激信号,活化后能诱导免疫和炎症应答。NLRP3炎症小体是中枢神经系统中研究最广泛的炎症小体。小胶质细胞、血管周围的巨噬细胞和脑膜巨噬细胞均能表达炎症小体,而炎症小体与急性脑部感染、急性无菌性脑损伤、帕金森病和阿尔茨海默病等的发生发展有密切关系。基于炎症小体与中枢神经系统疾病相关的机制探索和靶向药物开发是目前的研究热点。 |
| 关 键 词： | 炎症小体 中枢神经系统 小胶质细胞 巨噬细胞 帕金森病 阿尔茨海默病 |
| 收稿时间： | 2015-07-09 |
| 修稿时间： | 2015-10-15 |
Inflammasome and diseases of central nervous system |
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| DU Xiuming,ZHANG Ziteng,ZONG Ying,YU Chenlin,ZHANG Xiaodong and LU Guocai. Inflammasome and diseases of central nervous system[J]. The Journal of Pharmaceutical Practice, 2016, 34(1): 12-15 | |
| Authors: | DU Xiuming ZHANG Ziteng ZONG Ying YU Chenlin ZHANG Xiaodong LU Guocai |
| Affiliation: | Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China,Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China,Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China,Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China,Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China and Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China |
| Abstract: | Inflammasome is the body of protein complex which is able to identify different stimulation signals and can induce immune and inflammatory responses when it is activated. NLRP3 inflammasome has been extensively studied in the central nervous system. Microglia, perivascular macrophages and meningeal macrophages express inflammasomes. The occurrence and development of acute brain infection, aseptic acute brain injury, Parkinson disease and Alzheimer disease are closely related to inflammasomes. Based on mechanisms exploration of the inflammasome's role in the central nervous system disorders, its target drug research and development will be greatly addressed in the future. |
| Keywords: | inflammasome the central nervous system microglia macrophages Parkinson disease Alzheimer disease |
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