黄花倒水莲水提液的活血、抗炎作用研究

目的：本文对黄花倒水莲(PFH)水提液的活血、抗炎作用进行研究。方法：采用高分子右旋糖苷所致大鼠急性血癌模型、小鼠耳廓微循环观察、家兔体外血小板聚集、二甲苯或组胺所致小鼠急性炎症模型及PC—DTH等实验，考察PFH的作用。结果：PFH可显著降低右旋糖苦所致急性血癌大鼠的全血比粘度和还原比粘度；极显著扩张小鼠耳廓微动脉、微静脉，增加毛细血管开放数；对ADP诱导的家兔体外血小板聚集无明显影响；极显著抑制二甲苯所致小鼠耳廓肿胀及组织胺引起小鼠皮肤通透性增加；对6-三硝基氯苯诱导小鼠迟发型变态反应的诱导相、攻击相有显著抑制作用。结论：PFH具有显著活血、抗炎作用，为阐明其传统功效提供一定药理学依据。

Blood-activating and Anti-inflammatory Actions of Polygala fallax

Objective:To observe the blood-activating and anti-inflammatory actions of Polygala fallax Hesml. (PFH) in this paper. Methods: A series of experiments were performed to show the blood-activating and anti-inflammatory actions of PFH, including a-cute blood-stagnation model in rats induced by dextran of high molecular mass, observation on microcirculation in mice, platelet aggregation in vitro in rabbits, acute inflammation in mice induced by xylene or histamine, and PC-DTH. Results:PFH could remarkably decrease the whole blood relative viscosity. PFH could significantly dilate the micro-artery and micro-vein, increase the opening number of capillary in mice. However, PFH had no obvious effect on platelet aggregation induced by ADP in rabbits. PFH could significantly inhibit the increase of capillary permeability induced by histamine in mice, and decrease the mice ear-swelling induced by xylene. PFH could remarkably inhibit the induction-phase and attack-phase of PC-DTH in mice. Conclusion:The results suggested that PFH could improve the hemorrheologic character in blood-stagnation state, invigorate the micro-circulation, and inhibit inflammation process.