| 溃疡性结肠炎患者肠黏膜CD4CD25调节性T细胞及Foxp3表达水平的研究 |
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| 引用本文： | 谢睿,杨晓钟,缪林,李全朋,葛贤秀.溃疡性结肠炎患者肠黏膜CD4CD25调节性T细胞及Foxp3表达水平的研究[J].医药论坛杂志,2011(16):4-7,10. |
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| 作者姓名： | 谢睿 杨晓钟 缪林 李全朋 葛贤秀 |
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| 作者单位： | 南京医科大学第二附属医院消化医学中心;南京医科大学附属淮安一院消化内科; |
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| 基金项目： | 江苏省高校自然科学研究计划资助项目(07KJD320150) |
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| 摘 要： | 目的 通过分析溃疡性结肠炎(UC)患者肠黏膜中CD4+CD25+调节性T细胞及其特异性标志物Foxp3的表达特点,探讨CD4+ CD25+调节性T细胞和Foxp3在UC发病机制中的作用.方法18例UC活动期患者和12例健康体检者作为正常对照组,分别经电子肠镜活检肠黏膜组织,以流式细胞术检测肠固有层单个核细胞( LPMC...
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| 关 键 词： | 溃疡性结肠炎 调节性T细胞 Foxp3 CD4+T细胞 流式细胞术 |
Study on expression of CD_4~+CD_(25)~+ regulatory T cells and Foxp3 in intestinal mucosa of patients with ulcerative colitis |
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| XIE Rui,YANG Xiao-zhong,MIAO Lin,LI Quan-peng,GE Xian-xiu Institute of Digestive Endoscopy , Medical Center for Digestive Diseases,the SecondAffiliated Hospital of Nanjing Medical University,Nanjing ,China.Study on expression of CD_4~+CD_(25)~+ regulatory T cells and Foxp3 in intestinal mucosa of patients with ulcerative colitis[J].Journal of Medical Forum,2011(16):4-7,10. |
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| Authors: | XIE Rui YANG Xiao-zhong MIAO Lin LI Quan-peng GE Xian-xiu Institute of Digestive Endoscopy Medical Center for Digestive Diseases the SecondAffiliated Hospital of Nanjing Medical University Nanjing China |
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| Institution: | XIE Rui,YANG Xiao-zhong,MIAO Lin,LI Quan-peng,GE Xian-xiu Institute of Digestive Endoscopy and Medical Center for Digestive Diseases,the SecondAffiliated Hospital of Nanjing Medical University,Nanjing 210011,China |
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| Abstract: | Objective To analyze the characteristic of CD+4 CD+25 regulatory T cells and Foxp3 in intestinal mucosa of patients with ulcerative colitis(UC),and investigate their role in the pathogenesis of UC.Methods Totally 18 cases of active UC patients and 12 normal controls were enrolled in this study.The proportion of CD+4CD+25T cells and CD+4T cells in intestinal lamina propria mononuclear cells(LPMC) were assessed by flow cytometry,the expression of Foxp3 in intestinal mucosa was assessed by immunohistochemistry... |
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| Keywords: | Ulcerative colitis Regulatory T cells Foxp3 CD 4T cells Flow cytometry |
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