A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors |
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| Authors: | Dr Ikuko Kato Dr Shigeto Miura Fijio Kasumi Takuji Iwase Hideya Tashiro Yoshihiro Fujita Hiroki Koyama Tadashi Ikeda Kiyoshi Fujiwara Keiichi Saotome Kazuaki Asaishi Rikiya Abe Mitsuhiro Nihei Tsunehiro Ishida Takao Yokoe Hiroshi Yamamoto Motoi Murata |
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| Institution: | (1) Division of Epidemiology, Aichi Cancer Center, Nagoya;(2) Department of Breast Surgery, Aichi Cancer Center, Nagoya;(3) Department of Surgery, Cancer Institute Hospital, Tokyo;(4) Department of Breast Surgery, National Kyushu Cancer Center, Fukuoka;(5) Division of Surgery, Chiba Cancer Center, Chiba;(6) Department of Epidemiology, Chiba Cancer Center, Chiba;(7) Third Department of Surgery, The Center for Adult Diseases, Osaka;(8) Department of Surgery, School of Medicine, Keio University, Tokyo;(9) Department of Surgery, Section 1, Sapporo Medical College & Hospital, Sapporo;(10) Second Department of Surgery, Fukushima Medical College, Fukushima;(11) Second Department of Surgery, School of Medicine, Gunma University, Maebashi;(12) Department of Surgical Oncology, National Cancer Center, Tokyo, Japan;(13) Director's Office, International Agency for Research on Cancer, 150, cours Albert-Thomas, 69372 Lyon cedex 08, France |
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| Abstract: | Summary To study the effects of family history and reproductive, anthropometric, and dietary factors on the risk of breast cancer among low risk populations, we conducted a hospital-based case-control study involving 908 patients with breast cancer and their matched controls, in Japan. A positive family history of breast cancer significantly increased the risk of breast cancer (odds ratio = 1.52, 95% confidence interval: 1.14–2.03). The risk further increased with increasing number of family members affected. Obesity, single marital status, fewer births, a late childbirth, and less consumption of green-yellow vegetables and dairy products were also associated with an increased risk of breast cancer. These associations were independent in multivariate analyses. There was no increase in risk associated with consumption of high fat foods. When analyzed by menopausal status, the association with family history of breast cancer, especially in the first degree of relatives, was more evident for premenopausal breast cancer. The associations with obesity and lower consumption of dairy products were more pronounced for postmenopausal breast cancer, while those with lower parity and single marital status were stronger for premenopausal breast cancer. |
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| Keywords: | breast cancer family history reproductive history diet obesity |
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