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| 头孢三嗪和丁胺卡那霉素对肺炎大鼠免疫应答的调节作用 | |
| 引用本文： | 蔡少华 杨剑军. 头孢三嗪和丁胺卡那霉素对肺炎大鼠免疫应答的调节作用[J]. 军医进修学院学报, 1996, 17(2): 135-138 |
| 作者姓名： | 蔡少华 杨剑军 |
| 作者单位： | 解放军总医院南楼临床部一科 |
| 摘 要： | ４０只大鼠随机分为４组，３０只采用气管内注入感染法建立肺炎克雷白杆菌性肺炎模型，按成人常用临床治疗剂量折算在量的等效剂量。宫续７ｄ腹腔注射头孢三嗪和丁胺卡那霉素，活体取材测定免疫指标。 |
| 关 键 词： | 头孢三嗪 丁胺卡那霉素 肺炎 免疫学 |
The effects of ceftriaxone and amikacin on the immune response in rats pneumo-nia model |
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| Cai Shaohua,Yang Jianjun,Yao Hande,Huang Nianqiu. The effects of ceftriaxone and amikacin on the immune response in rats pneumo-nia model[J]. Academic Journal of Pla Postgraduate Medical School, 1996, 17(2): 135-138 | |
| Authors: | Cai Shaohua Yang Jianjun Yao Hande Huang Nianqiu |
| Abstract: | Forty Wistar rats were randomly divided into 4 groups.Thirty rats were infected with pneumoniaeKlebiella species by the intratracheal peroral routs,Ceftriaxone(CRO)and amikacin(AMK)were adiminis-tered at therapeutic doses intraperitoneally for 7 days and several immunologic parameters were measured.The results showed: (1)The weight of organs(thymus and spleen) and B cell density in the germinal centreof splenic follicles had no significant alteration in each groups;(2)CRO enhanced the chemoluminescenceplateau of polymorphonuclear leukocytes;(3)CRO increased the ACP activity,AMK decreased the phagocyto-sis and ADCC;(4)AMK decreased the number of CD and CD Tcells The resuIts indicated that CRO andAMK could advance or restrain the immune response in pneumonic rats,respectively. |
| Keywords: | ceftriaxone amikacin rats pneumonia immunology |
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