| 肾脏周细胞-肌成纤维细胞转分化的病理机制及中药的干预作用 |
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| 引用本文： | 刘莹露,石格,曹东维,万毅刚,吴薇,涂玥,刘不悔,韩文贝,姚建. 肾脏周细胞-肌成纤维细胞转分化的病理机制及中药的干预作用[J]. 中国中药杂志, 2018, 0(21): 4192-4197 |
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| 作者姓名： | 刘莹露 石格 曹东维 万毅刚 吴薇 涂玥 刘不悔 韩文贝 姚建 |
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| 作者单位： | 南京中医药大学中西医结合鼓楼临床医学院中医科;南京大学医学院附属鼓楼医院中医科;南京大学医学院附属鼓楼医院肾内科;南京中医药大学第二临床医学院中医养生学教研室;Division of Molecular Signaling |
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| 基金项目： | 国家自然科学基金面上项目(81573903)和国家自然科学基金青年基金项目(81603675);江苏省自然科学基金青年基金项目(BK20161046);江苏省高校自然科学研究面上项目(16KJB360004);南京市医学科技发展基金项目(QRX17042);南京市医学科技发展项目(YKK-15057,YKK-16097) |
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| 摘 要： | 在肾脏,周细胞(pericyte)是肾间质中肌成纤维细胞(myofibroblast,MyoF)的主要来源。周细胞-肌成纤维细胞转分化(pericyte-myofibroblast transition,PMT)是肾间质纤维化(renal interstitial fibrosis,RIF)重要病理机制之一,其中,周细胞的募集、活化与分离以及周细胞源性促红细胞生成素缺乏是促进RIF形成的主要原因。在PMT启动过程中,周细胞的活化及其与微血管的分离受控于多条信号转导途径,这些信号通路包括转化生长因子-β(transforming growth factor β,TGF-β)通路、血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)通路、血小板源性生长因子受体(platelet derived growth factor receptor,PDGFR)通路;阻断这些信号通路不仅能抑制PMT,而且,能遏制肾脏毛细血管减少,改善RIF。临床上,很多中药复方、单味中药及其提取物等都具有改善RIF的明确疗效,其中,一些中药的干预作用可能与周细胞及其PMT相关。基于此,"PMT及其药物干预的研究"将会成为中药抗脏器纤维化研究领域的重要发展方向。
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| 关 键 词： | 肾间质纤维化 周细胞 周细胞-肌成纤维细胞转分化 血管内皮生长因子受体信号通路 血小板源性生长因子受体信号通路 |
Pathomechanisms of pericyte-myofibroblast transition in kidney and interventional effects of Chinese herbal medicine |
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| LIU Ying-lu,SHI Ge,CAO Dong-wei,WAN Yi-ganga,WU Wei,TU Yue,LIU Bu-hui,HAN Wen-bei,YAO Jian. Pathomechanisms of pericyte-myofibroblast transition in kidney and interventional effects of Chinese herbal medicine[J]. China Journal of Chinese Materia Medica, 2018, 0(21): 4192-4197 |
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| Authors: | LIU Ying-lu SHI Ge CAO Dong-wei WAN Yi-ganga WU Wei TU Yue LIU Bu-hui HAN Wen-bei YAO Jian |
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| Affiliation: | (Department of Traditional Chinese Medicine,Nanfing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Traditional Chinese Medicine,Nanfing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Nephrology,Nanfing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008,China;Department of Traditional Chinese Medicine Health Preservation,Second Clinic Medical School, lYanjing University of Chinese Medicine,Nanjing 210023,China;Division of Molecular Signaling,Department of Advanced Biomedical Research,Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi,Yamanashi 409-3898,Japan) |
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| Abstract: | LIU Ying-lu;SHI Ge;CAO Dong-wei;WAN Yi-ganga;WU Wei;TU Yue;LIU Bu-hui;HAN Wen-bei;YAO Jian(Department of Traditional Chinese Medicine,Nanfing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Traditional Chinese Medicine,Nanfing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Nephrology,Nanfing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008,China;Department of Traditional Chinese Medicine Health Preservation,Second Clinic Medical School, lYanjing University of Chinese Medicine,Nanjing 210023,China;Division of Molecular Signaling,Department of Advanced Biomedical Research,Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi,Yamanashi 409-3898,Japan) |
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| Keywords: | renal interstitial fibrosis pericyte pericyte-myofibroblast transition vascular endothelial growth factor receptor pathway platelet derived growth factor receptor pathway |
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