AMI患者治疗前后血浆ET和NPY水平的变化及临床意义

目的:探讨了急性心肌梗死(AMI)患者血浆内皮素(ET)、神经肽Y(NPY)水平的变化。方法:应用放射免疫分析对36例急性心肌梗死患者进行了血浆ET、NPY测定,并与35名正常健康人作比较。结果:急性心肌梗死患者治疗前血浆ET、NPY水平显著地高于正常人组水平(P<0.01),治疗后一个月仍高于正常组水平(P<0.05)。结论:测定急性心肌梗死患者血浆ET、NPY水平对观察病情和预后判定具有重要的临床价值。

Clinical Significance of Changes of Plasma ET and NPY Levels After Treatment in Patients with AMI

Objective To investigate the changes of plasma ET and NPY levels in patients with AMI. Methods Plasma ET and NPY levels were dynamically determined in 36 patients with AMI right after establishment of diagnosis and 8h, 24h, 48h, 72h, 7d, 14d later. Levels in 35 healthy individuals were taken as control. Results Before treatment was initiated, the levels of ET and NPY in patients with AMI were significantly higher than those in controls (P<0.01). After one week of treatment, the levels dropped toward normal. Conclusion Dynamic measurement of plasma ET and NPY levels in patients with AMI is of clinical importance.