CTLA-4基因多态性与儿童过敏性紫癜的相关性

过敏性紫癜是一种由自身免疫反应介导的全身性血管炎，T细胞功能紊乱是其发病的重要因素。细胞毒性T淋巴细胞相关抗原－4（CTLA-4）是免疫球蛋白超家族成员，人类CTLA-4基因位于2q33。 CTLA-4不仅对T细胞活化起负向调节作用，还可介导免疫耐受，诱导T细胞分化，维持机体细胞／体液免疫平衡，所以CTLA-4可能与T细胞介导的自身免疫性疾病有关。CTLA-4存在多位点的基因多态性，其多态性可影响CTLA-4的功能及其分子的表达，导致自身免疫性疾病，包括过敏性紫癜的发生发展，本文将对CTLA-4基因多态性与过敏性紫癜的相关性研究进行综述。

Association of CTLA-4 gene polymorphism and anaphylactoid purpura

Anaphylactoid purpura , also named Henoch-Schonlein Purpura ( HSP) , is an autoimmune-mediated systemic vasculitis with an important etiology of T-cell dysfunction .As member of super family of immunoglobulin , human cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is located on 2q33.CTLA-4 plays negative roles in regulating T-cell activation, mediates immune tolerance, induces T-cell differentiation and maintains the balance of cell-mediated/humoral immunity .Therefore , CTLA-4 may be associated with the T-cell-mediated autoimmune disease .Studies show that CTLA-4 presents gene polymorphism in several loci , which affect the function and expression of CTLA-4, leading to autoimmune disease including HSP .Here was a review for the association of CTLA-4 gene polymorphism and HSP .