子宫内膜异位症相关卵巢癌病因研究进展

子宫内膜异位症(endometriosis,EMs)在病理学表现上虽为良性病变,但具有与恶性肿瘤相似的浸润、种植生长、破坏周围组织、远处转移和极易复发的特点,并有一定比例的EMs会发生组织形态学改变,从非典型内膜异位组织进一步转变成癌。目前EMs恶变已受到世界各地学者的广泛关注。EMs和卵巢癌的组织联系虽早已被学者提出,并有公认的诊断标准,但是随着近年来EMs和卵巢癌发病率的增加,子宫内膜异位症相关卵巢癌(endometriosisassociated ovarian cancer,EAOC)愈发引起学者的重视,其病因、发病机制、流行病学特征等已成为近年的研究热点。就近年的研究成果主要从基因突变、细胞凋亡、炎症免疫、氧化应激、雌激素5个方面对EAOC的病因和发病机制进行阐述。

Advances in the Etiology of Endometriosis-associated Ovarian Cancer

Endometriosis (EMs) is a benign lesions on pathology, but it has similar characteristics with malignant tumor such as infiltration, plant growth and damage the surrounding tissue, distant metastasis, and easy to relapse. Moreover, having a certain proportion of EMs histomorphology changes will happen, from atypical endometrial ectopic tissues further into cancer. Recently, EMs malignant transformation has received extensive attention of scholars from all over the world. Although the connection between EMs and ovarian cancer has been reported by scholars and has accepted diagnostic criteria, with the increase of the incidence of endometriosis and ovarian cancer, etiology, mechanisms and the epidemiological characteristics of endometriosis-associated ovarian cancer (EAOC) have become a research focus in recent years. This artical is to review the current data regarding the pathogenesis of EMs malignant transformation associated with gene mutation, apoptosis, inflammation, immunity, oxidative stress, estrogen.