我国不同人群单纯疱疹病毒2型感染率及危险因素Meta分析

目的 了解我国不同人群单纯疱疹病毒2型(HSV-2)感染率水平及其危险因素.方法 采用Statal2.0对我国不同人群HSV-2感染率及相关危险因素数据进行meta分析、应用SPSS22.0进行亚组间统计学检验.结果 普通人群HSV-2感染率为16.22％ (95％ CI:12.87％ ～ 19.91％),女性高于男性,分别为16.89％(95％ CI:12.91％～21.32％)和11.69％ (95％ CI:9.07％ ～ 14.56％).不同人群既往感染率各不相同,以女性性工作者(FSW) 44.77％ (95％ CI:38.47％ ～ 46.36％)较高.多数高危人群感染率高于普通人群.随着时间推移,普通人群既往和近期感染率呈下降趋势,高危人群既往HSV-2感染率先升后降.影响因素分析提示性别、梅毒感染、HIV阳性等是感染HSV-2的危险因素.结论 我国不同人群HSV-2感染率较高,以女性、高危人群和疑与HSV-2感染相关疾病患者更为突出.建议将HIV干预和包括HSV-2在内的性病相结合、加强HSV-2监测、加强育龄妇女及孕妇HSV-2检测控制HSV-2传播.

Meta-analysis on the prevalence and risk factors of herpes simplex virus type 2 infection among different populations in China

Objective To estimate the prevalence and risk factors of herpes simplex virus type 2 (HSV-2) among different population in mainland China.Methods Stata 12.0 was used to review the original research published papers on the prevalence and risk factor of HSV-2 in mainland China.SPSS 22.0 was applied to analyze the statistical difference among groups.Results The pooled retrospective prevalence of the general population is 16.22％ (95％ CI:12.87％-19.91％),and the prevalence in female with 16.89％ (95％CI:12.91％-21.32％) was higher than that in male with 11.69％ (95％ CI:9.07％-14.56％).Different groups have different retrospective prevalence.Among them,FSW has the higher one.Most of the retrospective prevalence of high risk groups was higher than that of the general population.The tendency of retrospective and recent prevalence over time decreases significantly in general population,while the tendency of retrospective prevalence among high risk group also ascended first and descended secondly.Our study certified that sex,syphilis and HIV infection increased the risk of HSV-2 infections.Conclusions The pooled HSV-2 prevalence in different groups was higher,especially among female,high risk groups and patients with diseases probably caused by HSV-2 infection.It was suggested to combine HSV-2 related education with the HIV comprehensive intervention,as well as enhancing HSV-2 surveillance and testings among pregnant and fertile women for the control of HSV-2.