肿瘤细胞凋亡核素显像分子探针研究进展

测定肿瘤细胞凋亡是早期评价肿瘤疗效的指标之一, 放射性核素凋亡显像是目前研究最为广泛、技术最为成熟的体内肿瘤细胞凋亡分子影像学检测技术, 能在活体内动态、无创地检测抗肿瘤治疗引起的细胞凋亡, 有助于肿瘤疗效的早期评判和预后分析, 其中特异性分子探针技术的研究开发是放射性核素凋亡显像的关键技术之一。笔者将目前有代表性的肿瘤细胞凋亡核素显像分子探针进行了总结。

Progress in molecular probes of radionuclide tumor apoptosis imaging

Apoptosis is one of the important indices about the early assessment of the efficacy of tumor treatment.Among molecular imaging techniques of tumor apoptosis,radionuclide imaging is the most extensively studied and the most sensitive imaging modality,which can noninvasively and dynamically detect cell apoptosis induced by treatment in vivo,especially for efficacy of cancer therapies and prognosis of malignancies.Recently,as one of the key techniques,specific molecular probes are being developed.The representative molecular probes of the radionuclide imaging for tumor apoptosis are reviewed.