促甲状腺素及其受体与骨质疏松关系的研究进展

骨质疏松症(OP)是严重威胁老年人身心健康的常见疾病。随着人口老年化,老年性骨质疏松症发病率逐年增加。近年来内分泌性骨质疏松日见增多,促甲状腺激素(TSH)及促甲状腺激素受体(TSHR)与骨量减少、骨质疏松的关系倍受关注。成骨细胞和破骨细胞上的促甲状腺激素受体的作用是造成这一作用的关键。而此过程还会受到2型碘化甲腺氨酸脱碘酶、肿瘤坏死因子(TNF)等的影响。同时促甲状腺激素受体存在基因多态性,对其功能存在不同程度的影响,也可能是造成骨质疏松的重要原因。通过对这个领域的深入研究为内分泌性骨质疏松的防治提供依据。

The investigation advancement of the relationship between osteoporosis and thyrotropin as well as receptors of thyrotropin

Osteoporosis is a common disease that severely threaten physical and mental health of the aged people. With the senescence of population,the incidence of senile osteoporosis is increasing every year. In the past few years,with the increase of endocrine osteoporosis,the relationship between thyroid stimulating hormone,receptors of thyroid stimulating hormone and osteopenia,osteoporosis has been paid close attention to it.In this course, receptors of thyroid stimulating hormone in the osteoclasts and osteoblasts play a key role. At the same time, type 2 Iodothyronine Deiodinase and tumor necrosis factor also impact on the course.Further more polymorphism presented in receptors of thyroid stimulating hormone,which affected the it's function,and even result in osteoporosis.Through the study and research in this domain, evidence of prevention and cure of endocrine osteoporosis could be provided.