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| Pharmacodynamic study of recombinant human erythropoietin on a renal anemia model induced by gentamycin in rats | |
| 引用本文： | 曹之舫,贾林,姜蓉,高丽华,潘学工,陆德如. Pharmacodynamic study of recombinant human erythropoietin on a renal anemia model induced by gentamycin in rats[J]. 中国人民解放军军医大学学报, 1996, 0(1) |
| 作者姓名： | 曹之舫 贾林 姜蓉 高丽华 潘学工 陆德如 |
| 作者单位： | Department of Immunopharmacology，Institute of Medical Biotechnology and Molecular Genetics，Second Military Medical University，Shanghai，200433 |
| 摘 要： | ＰｈａｒｍａｃｏｄｙｎａｍｉｃｓｔｕｄｙｏｆｒｅｃｏｍｂｉｎａｎｔｈｕｍａｎｅｒｙｔｈｒｏｐｏｉｅｔｉｎｏｎａｒｅｎａｌａｎｅｍｉａｍｏｄｅｌｉｎｄｕｃｅｄｂｙｇｅｎｔａｍｙｃｉｎｉｎｒａｔｓＣａｏＺｈｉｆａｎｇ（曹之舫）；ＪｉａＬｉｎ（贾林）；Ｊｉ... |
Pharmacodynamic study of recombinant human erythropoietin on a renal anemia model induced by gentamycin in rats |
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| Cao Zhifang, Jia Lin, Jiang Rong, Gao Lihua, Pan Xuegong,Lu Deru. Pharmacodynamic study of recombinant human erythropoietin on a renal anemia model induced by gentamycin in rats[J]. Journal of Medical Colleges of PLA(China), 1996, 0(1) | |
| Authors: | Cao Zhifang Jia Lin Jiang Rong Gao Lihua Pan Xuegong Lu Deru |
| Abstract: | It was demonstrated pathologically that the histological structures of kidneys were impaired after subcutaneous injection of gentamycin for 16 consecutive days in rats. Laboratory parameters showed that serum blood urea nitrogen(BUN) and creatinine (Cr) elevated, while the indices of the erythrogenic line reduced markedly, and erythropoietin (EPO) was not detectable by ELISA. When the rats received recombinant human erythropoietin (rhEPO) for 5 d, the level of EPO in serum went up, and the indices of reticulocyte, red blood cell (RBC),hemoglobin (Hb) and hematocrit (Hct) improved rapidly, of which the response of reticulocyte was most sensitive. The results suggested that the erythrogenic function of the bone marrow in rats was enhanced after the stimulation of rhEPO, and the effect of rhEPO was dose dependent. |
| Keywords: | erythropoietin gentamycin anemia renal renal failure pharmacodynamics rats |
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