活血利水法对左心室射血分数正常心力衰竭患者心功能及血清NT-proBNP水平的影响

目的探讨活血利水法对左心室射血分数正常心力衰竭（heartfailurewithnormalejectionfraction，HFNEF）患者心功能及血清N末端脑利钠肽原（NT—proBNP）水平的影响。方法将64例HF—NEF患者随机分为对照组和治疗组，各32例。对照组行常规西药治疗，治疗组在西药治疗基础上加服活血利水中药方剂。观察两组患者治疗前后中医证候变化、舒张早期二尖瓣血流峰速度／舒张早期二尖瓣舒张速度（E／E’）及血清NT—proBNP含量的变化。结果与治疗前比较，两组患者治疗后中医证候、E／E＇均明显改善，血清NT—proBNP值均减小，差异有统计学意义（P〈0．05）；与对照组比较，治疗组中医证候改善明显，E／E’、NT—proBNP明显下降，差异有统计学意义（P〈0．05）。结论活血利水法联合西药治疗HFNEF疗效确切，可改善HFNEF患者心脏舒张功能．降低血清NT．DroBNP水平。

Effect of Blood Activating Water Relieving Method on Heart Functions and Serum Levels of NT-proBNP in Patients with Heart Failure with Normal Ejection Fraction

Objective To study the effect of blood activating water relieving method （BAVVRM） on heart functions and serum levels of NT-proBNP in patients with heart failure with normal ejection fraction （HF- NEF）. Methods Sixty-four HFNEF patients were admitted to our hospital during January 2011 to June 2012. They were randomly assigned to the treatment group （32 cases ~） and the control group （32 cases）. Patients in the control group received routine Western medical treatment, while those in the treatment group additionally took Chinese medical recipes for activating blood circulation and relieving water retention. Changes of Chinese medical syndromes, E/E＇, serum NT-proBNP contents were observed between the two groups. Results Com- pared with before treatment, their Chinese medical syndromes and E/E＇ were significantly improved, and ser- um NT-proBNP contents decreased in the two groups （P 〈0.05）. Compared with the control group, Chinese medical syndromes, EIE＇, serum NT-proBNP contents obviously decreased in the treatment group, showing statistical difference （P 〈0.05）. Conclusion BAWRM was an effective way to improve the diastolic function of HFNEF patients and lower the serum level of NT-proBNP with confirmative efficacy.