妊娠高血压综合征病人血清白细胞介素-6 水平的测定

①目的探讨妊娠高血压综合征(妊高征)病人血清IL-6水平的变化及其与妊高征发病的关系.②方法采用双抗体夹心酶联免疫吸附法(ELISA),测定了60例妊高征病人(其中轻度、中度、重度各20例)及35例正常晚期妊娠妇女血清IL-6浓度.③结果妊高征组血清IL-6含量明显高于正常妊娠组,差异有显著性(t=2.165,P＜0.05).中、重度妊高征组IL-6含量与轻度及正常妊娠组比较,差异有显著性(F=8.412,q=4.365～6.053,P＜0.05、0.01),轻度妊高征组IL-6含量与正常妊娠组比较,差异无显著性(q=2.102,P＞0.05).④结论血清中IL-6的升高参与了血管内皮损伤过程,IL-6可能在妊高征的发病过程中起一定的作用.

DETERMINATION OF INTERLEUKIN-6 IN SERUM OF PATIENTS WITH PREGNANCY-INDUCED HYPERTENSION

Objective To study the changes of serum interleukin-6(IL-6) in patients with pregnancy-induced hypertension(PIH) and the relationship between IL-6 and the genesis of PIH. Methods Serum levels of IL-6 of 60 PIH women (including 20 with mild PIH, 20 moderate, and 20 severe) and 35 normal pregnant ones were measured by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-6 in the PIH group were significantly higher than those in the control group (t= 2.165 ,P<0.05). Serum levels of IL-6 in the moderate and severe PIH groups were significantly higher than those in the mild PIH group and control group (F=8.412,q=4.365-6.053,P<0.05,0.01). No difference existed between the serum levels in the mild PIH and control groups (q=2.102,P>0.05). Conclusion The increased levels of serum of IL-6 may participate in the vascular endothelium damages in PIH. IL-6 may play a role in the genesis of PIH.