奥曲肽治疗上消化道大出血28例的疗效探析

目的探讨奥曲肽用于消化道大出血的临床治疗效果。方法选取本院2010年6月-2012年6月收治的消化道大出血患者共56例，随机分为观察组与对照组，每组各28例。对照组给予补液、止血、输血、泮托拉唑抑酸剂治疗，观察组在对照组基础上加用奥曲肽治疗，持续治疗48h，对比两组患者止血情况及不良反应情况。结果观察组患者治疗48h后仅1例患者肠鸣音活跃及仍排黑便，治疗无效，其余27例病例症状均恢复正常，治疗有效，有效率为96．43％；对照组治疗48h后，有效13例，无效15例，有效率为46．43％；两组差异有统计学意义（P〈0．05）；15例患者共47项指标异常（P〈0．05）；观察组不良反应产生率为7．14％，对照组为39．29％，两组差异有统计学意义（P〈0．05）。结论奥曲肽治疗上消化道大出血效果良好，不良反应少，值得在临床上推广应用。

Therapeutic effect ,analysis of octreotide for 28 cases of upper gastroin- testinal bleeding

Objective To investigate the therapeutic effect of octreotide for upper gastrointestinal bleeding. Methods Total of 56 patients with upper gastrointestinal bleeding treated in our hospital from June 2010 to June 2012 were ran- domly assigned to observation group and control group, 28 cases respectively. The control group was given fluid infu- sion, arresting bleeding, blood transfusion, and pantoprazole antacid therapy. The observation group was added contin- ued octreotide treatment of 48 hours on the base of the control group. The effect of arresting bleeding and adverse re- action of both groups was compared. Results After treatment of 48 hours, only 1 case in the observation group failed to treatment with active bowel sounds and still discharges black stools; the other 27 cases were all cured with symptoms back to normal and effective rate of 96.43%. While in control group, there were 13 cases of getting effect, 15 eases of no effect, and effective rate of 46.43% （P 〈 0.05）. There were total of 47 abnormal test indicators in 15 cases （P 〈 0.05）. The adverse reaction rates of observation group and control group was respectively 7.14% and 39.29% （P 〈 0.05）. Conclusion For upper gastrointestinal bleeding, octreotide has good effect of arresting bleeding, fewer reverse effect, and is worthy of widely application.