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CACNA1C (Ca(v)1.2) in the pathophysiology of psychiatric disease

Authors:	Bhat Shambhu Dao David T Terrillion Chantelle E Arad Michal Smith Robert J Soldatov Nikolai M Gould Todd D

Institution:	Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States.

Abstract:

Keywords:	AEI Allelic expression imbalance ANK3 Ankyrin 3 node of Ranvier (ankyrin G) APP Amyloid precursor protein BDNF Brain derived neurotrophic factor BPD Bipolar disorder CaBP1 Calcium binding protein-1 CACNA1C Voltage dependent L type calcium channel alpha 1C subunit CaM Calmodulin cAMP Cyclic adenosine monophosphate CaMK Ca2+/CaM-dependent protein kinases Ca_v1 1 to 1 4 Calcium voltage-dependent channel 1 1 to 1 4 representing the voltage of activation of the respective channel cDNA Complementary DNA CICR Calcium-induced intracellular calcium release CREB cAMP response element binding protein DHP Dihydropyridine DSM IV Diagnostic and Statistical Manual IV Erk Extracellular signal-regulated kinases GABA Gamma-aminobutyric acid GenRED Genetics of Recurrent Early-onset Major Depression consortium GWAS Genome-wide association study LD Linkage disequilibrium LTCC L-type calcium channel LTP long-term potentiation MAOI Monoamine oxidase inhibitor MAPK Mitogen-activated protein kinase MDD Major depressive disorder MIR137 microRNA 137 NAc Nucleus accumbens NIMH-GIBD National Institute of Mental Health-Genetics Initiative Bipolar Disorder consortium NMDA N-methyl-D-aspartate ODZ4 odd Oz/ten-m homolog 4 (Drosophila) OR Odds ratio PCR Polymerase chain reaction PGC Psychiatric Genetics Consortium RyR Ryanodine receptors SNP Single nucleotide polymorphism SSRI Selective serotonin reuptake inhibitor SZ Schizophrenia STARD study Sequenced treatment alternatives to relieve depression study TCA Tricyclic antidepressant VTA Ventral tegmental area WTCCC Wellcome Trust Case–Control Consortium ZNF804A* zinc finger protein 804A
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