卵巢子宫内膜异位囊肿血清糖链抗原-125的测定及其临床意义

目的 探讨血清糖链抗原-125 (CA125)与卵巢子宫内膜异位囊肿(ECO)的关系.方法 选择2009年7月至2010年12月于本院妇科诊治的62例ECO患者为研究对象,纳入研究组;选择同期在本院住院手术治疗的卵巢良性囊肿[不合并子宫内膜异位症(EMs)]患者62例,纳入对照组,均经术后组织病理学检查结果证实(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书).两组患者年龄、体重指数(BMI)等比较,差异无统计学意义(P＞0.0 5).采用微粒子酶免疫分析法分别测定两组患者的血清CA125水平,并进行相关统计学分析.结果 研究组血清CA125水平显著高于对照组[(95.36±56.31)U/mL vs.(18.64±7.45) U/mL],两组比较,差异有统计学意义(P＜0.01).研究组血清CA125水平与EMs分期(病情严重程度)呈显著正相关关系(r=0.8832,P＜0.01),并且EMsⅡ～Ⅳ期患者的血清CA125水平较EMs Ⅰ期显著升高,差异有统计学意义(P＜0.01);EMsⅡ期与EMsⅢ期患者血清CA125水平比较,差异亦有统计学意义(P＜0.01).研究组血清CA125水平与痛经评分(DSS)呈正相关关系(r=0.5650,P＜0.01),并且DSS为1～3分患者与0分患者的血清CA125水平比较,差异均有统计学意义(P＜0.01).结论 血清CA125与ECO的发生发展及预后有关.ECO患者的血清CA125水平随着EMs分期(EMs严重程度)增加而升高,与DSS均呈正相关关系.测定血清CA125有助于对ECO的诊断及对病情、预后的判断.

Measurement of Serum Carbohydrate Antigen-125 in Patients With Endometrial Cysts of the Ovarian and Its Clinical Significance

Objective To study the relationship between serum carbohydrate antigent-125 ( CA125 ) and endometrial cysts of ovary ( ECO ) .Methods From 2009July to 2010December , a total of 62cases women with ECO were included in study group , during the same period and in the same hospital , 62cases with endometriosis ( EMs ) benign ovarian cysts included in control group , all accepted operation treatment and confirmed by postoperative histopathological examination.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chengdu Women and Children′s Central Hospital. Informed consent was obtained from all participants.There had no significance difference between two groups among ages , body mass index ( BMI ) and etc. ( P>0.05 ) .Levels of serum CA125 in two groups were measured by microparticle enzyme immunoassay , and analysis by statistics methods.Results Levels of serum CA 125 in study group were significantly higher than those in control group [( 95.36±56.31 ) U / mL vs. ( 18.64±7.45 ) U / mL ], There had significance difference ( P<0.01 ) .In study group , the relationship between levels of serum CA125 and severity of EMs ( EMs stages ) had a positive correlation ( r=0.8832 , P<0.01 ); serum CA125 levels in patients of EMs Ⅱ-Ⅳ stages were much higher than those in EMs Ⅰ stage , and there had significant difference ( P<0.01 ), and here had significance difference between levels of serum CA 125 in EMsⅡstage andⅢstage ( P<0.01 ); levels of serum CA 125 and dysmenorrhea severity had apositive correlation ( r=0.5650 , P<0.01 ), and there had significance difference between levels of dysmenorrhea severity scores ( DSS ) 1-3and 0 ( P<0.01 ) .In study group , relationship between levels of serum CA 125 and dysmenorrhea severity also had a positively correlated ( P<0.01 ) .Conclusions Levels ofserum CA 125 has bearing on the occurrence , development and prognosis of EOC , Levels of serum CA 125 had a positively correlated with EMs stages and DSS.