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| 肝癌细胞株雌二醇与uPAR表达的关系 | |
| 引用本文： | 王文奇 吴洪文 徐瀚峰 时昌文 刘倩. 肝癌细胞株雌二醇与uPAR表达的关系[J]. 医学信息, 2005, 18(10): 1341-1342 |
| 作者姓名： | 王文奇 吴洪文 徐瀚峰 时昌文 刘倩 |
| 作者单位： | 山东大学山东省千佛山医院,山东济南250014 |
| 摘 要： | 目的 观察人肝癌BEL-7402细胞株中雌二醇与uPAR表达的关系。方法 将肝癌BEL-7402细胞株培养于不同浓度雌二醇的培养液中，培养24h、48h及72h后收集各组细胞。通过免疫组化实验，检测各组细胞uPAR的表达。结果 雌二醇作用后的BEL-7402细胞uPAR表达的阳性率明显高于对照组（P〈0．05）。结论 雌二醇可促进肝癌BEL-7402细胞株uPAR的表达。 |
| 关 键 词： | 雌二醇 尿激酶型纤溶酶原激活物 尿激酶型纤溶酶原激活物受体 肝癌细胞 |
| 收稿时间： | 2005-06-24 |
| 修稿时间： | 2005-07-25 |
Relation between estradiol and urokinase type plasminogen activator receptor (uPAR) of human hepatoma cells |
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| Wang WenJi;Wu HongWen;Xu HanFeng;Shi ChangWen;Liu Qian. Relation between estradiol and urokinase type plasminogen activator receptor (uPAR) of human hepatoma cells[J]. Medical Information, 2005, 18(10): 1341-1342 | |
| Authors: | Wang WenJi Wu HongWen Xu HanFeng Shi ChangWen Liu Qian |
| Abstract: | Objective To observe the relation between estradiol and urokinase type plasminogen activator receptor (uPAR) of human hepatoma cells BEL- 7402. Methods The hepatoma cells were treated with varies contentions estradiol ,incubating 24h,48h and 72h. The expression of uPAR were detected using the polyclonal antibody by S- P immunohistochemistry. Results The expression of uPAR after the treatment of estradiol were higher than the control group (P<0.05),showing time- dependant and concentration- dependant relationship. Conclusion Estradiol can effectively enhance the expression of uPAR. |
| Keywords: | estradiol urokinase type plasminogen activator urokinase type plasminogen activator receptor hepatoma carcinoma cell |
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