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| RUNX3和CD44v6在非小细胞肺癌中的表达及意义 | |
| 引用本文： | 张菡菡. RUNX3和CD44v6在非小细胞肺癌中的表达及意义[J]. 滨州医学院学报, 2011, 34(1): 22-25 |
| 作者姓名： | 张菡菡 |
| 作者单位： | 滨州医学院生物化学教研室,烟台市,264003 |
| 摘 要： | 目的探讨非小细胞肺癌中RUNT相关转录因子3（RUNX3）和CD44v6的表达及其与肿瘤生物学行为的关系。方法应用免疫组化SP法对72例非小细胞肺癌组织及72例癌旁组织进行RUNX3和CD44v6蛋白检测。结果 RUNX3阳性染色定位于细胞核,阳性表达率为30.56%,显著低于癌旁组织（88.89%,P〈0.01）,其表达强度与非小细胞肺癌的组织学分级、临床分期及淋巴结转移相关（χ2=6.244～17.78,P均〈0.05）,与病理类型无关（χ2=1.802,P〉0.05）;CD44v6阳性染色定位于细胞质,阳性表达率为68.05%,显著高于癌旁组织（5.56%,P〈0.01）,其表达强度与非小细胞肺癌的组织学分级、淋巴结转移及临床分期显著相关（χ2=9.901～16.86,P均〈0.01）,鳞癌的CD44v6的表达率与腺癌差异有显著性（χ2=7.266,P〈0.05）;RUNX3和CD44v6的表达强度与原发瘤直径及病人的年龄、性别均无关（P均〉0.05）;肺癌组织中RUNX3和CD44v6的表达强度呈显著负相关（r=-0.44,P〈0.01）。结论 RUNX3和CD44v6在非小细胞肺癌的发生发展过程中有一定的作用,联合检测RUNX3和CD44v6可作为判定非小细胞肺癌恶性程度及评估其侵袭性、转移性的重要方法。 |
| 关 键 词： | RUNT相关转录因子3 CD44v6 非小细胞肺癌 免疫组织化学 |
Expression and significance of RUNX3 and CD44v6 in non-small-cell lung cancer |
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| ZHANG Hanhan. Expression and significance of RUNX3 and CD44v6 in non-small-cell lung cancer[J]. Journal of Binzhou Medical College, 2011, 34(1): 22-25 | |
| Authors: | ZHANG Hanhan |
| Affiliation: | ZHANG Hanhan Department of Biochemistry,Binzhou Medical University,Yantai 264003 |
| Abstract: | Objective To investigate the relationship of the expression of the new type of anti-oncogene RUNX3,the adhesion molecule CD44v6 and biological behavior in non-small-cell lung cancer(NSCLC)tissue.Methods Streptavidin peroxidase immunohistochemical method was used to detect the expression of RUNX3 and CD44v6 protein in 72 NSCLC tissue samples and 72 corresponding normal lung tissue samples.Results RUNX3 was expressed in nuclear.The positive rate of RUNX3 in NSCLC is 30.56%,which was significantly lower than t... |
| Keywords: | CD44v6 |
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