有偿献血员人类免疫缺陷病毒合并乙型、丙型肝炎病毒感染及生化指标分析

目的: 探讨有偿献血员中人类免疫缺陷病毒(HIV)合并乙型、丙型肝炎病毒(HCV、HBV)感染情况及其肝、肾功能指标的变化。方法: 选取125例曾有偿献血HIV感染者,进行HCV、HBV血清学标志物及肝、肾功能各项指标检测。结果: 125例中,合并HCV感染率为92.0%,合并HBV感染率为5.6%,合并HCV感染组AST、ALT与对照组和单纯HIV感染组差异均有统计学意义。HIV合并HCV、HBV感染组及单纯HIV感染组β₂微球蛋白与对照组差异有统计学意义,合并HCV组与单纯HIV感染组β₂微球蛋白差异有统计学意义(P < 0.01)。结论: HIV合并HCV可加重HIV患者的肝脏损害,对肾功能未造成影响,β₂微球蛋白升高可能是机体免疫过度活化的表现。

Analysis of serum biochemical indicator of human immunodeficiency virus infected blood donors co-infected with hepatitis C virus or hepatitis B virus

Objective：To explore the changes of liver and kidney function indicators in human immunodeficiency virus（HIV） infected blood donors co-infected with hepatitis C virus（HCV） or hepatitis B virus（HBV）.Methods：The serological markers of HCV and HBV,and all indicators of liver and kidney were detected among 125 HIV infected blood donors and 40 health cases as control.Results：The infection rate of HCV was 92.0% and 5.6% of HBV among 125 HIV infected blood donors.There were statistical differences of ALT,AST between HIV co-infected with HCV donors and health control cases,also with HIV infected alone donors.In contrast to health control group,there was significant difference of β2-MG in HIV co-infected with HBV or HCV and HIV infected alone donors.There was significant difference of β2-MG between HIV co-infected with HCV and HIV infected alone donors（P〈0.01）.Conclusions：HIV co-infected with HBV or HCV may accentuate the damage of liver function,and it seems no effect on kidney function.The rise of β2-MG may be the over-activation of host immunity.