小剂量胺碘酮联合倍他乐克在肥厚型心肌病伴恶性室性心律失常治疗中的应用研究

目的探讨和分析小剂量胺碘酮联合倍他乐克治疗肥厚型心肌病伴恶性室性心律失常治疗中的临床效果。方法将94例肥厚型心肌病伴恶性室性心律失常患者按照住院时间先后顺序分组为对照组和观察组;对照组:采用倍他乐克治疗;观察组:采用小剂量胺碘酮联合倍他乐克治疗。对两组患者进行为期6~12个月随访。结果观察组和对照组的治疗有效率分别为95.7%(45/47)、80.9%(38/47)。除QT间期最大值以外,两组心电图指标和LVEF治疗后均较治疗前显著改善(P0.05),观察组治疗后心率和QT间期最小值以及QT散度、LVEF、再住院率、猝死率等方面均优于对照组(P0.05)。治疗和随访期间均没有发现明显性不良反应。结论采用小剂量胺碘酮联合倍他乐克治疗肥厚型心肌病伴恶性室性心律失常,可有效地改善患者的临床症状,效果明确。

Low - dose amiodarone combined betaloc in hypertrophic cardiomyopathy with applied research in the treatment of malignant ventricular arrhythmia.

Objective To discuss and analyze the clinical effect of low - dose amiodarone combined with metoprolol in the treatment of hypertrophic cardiomyopathy associated with malignant ventricular arrhythmia. Methods The 94 cases of patients with malignant ventricular arrhythmia with hypertrophic cardiomyopathy according to the length of hospital stay were divided into control group and observation group. Control group received betaloc treatment. Observation group received low - dose amiodarone combined times betaloc treatment. The two groups of patients were followed up for 6 to 12 months. Results The treatment effectiveness of observation group and control group were 95.7 % （45/47）, 80.9% （38/47）. In addition to the maximum value of the QT interval, compared with before treatment, the ECG indicators and LVEF were significant improvement in both groups（ P 〈 0.05 ）. At the same time period between the two groups, the heart rate of improvement, QT minimum, QT dispersion degree, LVEF improved. The hospitalization rates and sudden death rate decreased （ P 〈 0.05 ）. During the treatment and follow -up, no significant adverse reactions were reported. Conclusion Using low - dose amiodarone combined with betaloc treatment, can effectively improve the patients clinical symptoms.