匹伐他汀的降糖效果及其治疗糖尿病高胆固醇血症的疗效

目的观察匹伐他汀的降糖效果及其治疗糖尿病高胆固醇血症的疗效。方法选取2012年1月至2013年3月就诊治疗的106例糖尿病高胆固醇血症患者作为研究对象,随机分为对照组和观察组各53例。所有患者在服用二甲双胍降糖药和控制饮食治疗的同时,对照组给予口服阿托伐他汀药物治疗,观察组给予匹伐他汀药物治疗,比较分析两种药物的降糖效果及降脂效果。结果与治疗前比较,观察组空腹血糖(FBS)和糖化血红蛋白(HbA1c)均显著降低(P0.05),对照组FBS、餐后血糖(PBG)、HbA1c变化均无显著性差异(P0.05);治疗后观察组FBS、HbA1c与对照组相比差异具有显著性(P0.05),而PBG两组比较差异无显著性(P0.05)。两组患者治疗前后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)比较差异均具有显著性(P0.05),治疗后观察组TC、TG和LDL分别降低了10.41%、17.92%和12.98%,对照组TC、TG和LDL-C分别降低了9.94%、15.97%和13.46%,组间比较差异无统计学意义(P0.05);而观察组HDL-C升高达9.12%,对照组HDL-C升高6.31%,观察组明显高于对照组,组间比较差异具有统计学意义(P0.05)。观察组不良反应发生率为3.77%,对照组不良反应发生率为7.55%,组间比较差异无显著性(P0.05)。结论匹伐他汀能够增加高密度脂蛋白胆固醇水平,而且对患者FBS和HbA1c的降低作用优于阿托伐他汀,是一种安全有效的治疗糖尿病高胆固醇血症的药物,值得临床广泛应用。

Pitavastatin effect and its effect on the treatment of diabetick blood sugar.

Objective To observe the efficacy of pitavastatin and its effect on blood glucose in diabetic treatment of hypercholesterolemia. Methods 106 cases of diabetic patients with hypercholesterolemia were selected from our hospital between January 2012 and March 2012 during clinic treatment. All of these patients were randomly divided into control group and observation group,53 cases in each group. All patients took metformin hypoglycemic agents and diet therapy at the same time. The control group received oral atorvastatin therapy. Observation group were giv-en pitavastatin medication. The blood sugar effects and efficacy were compared and analyzed in the two drugs for the treatment of. Results Com-pared with before treatment,FBS and HbA1c in observation group were significantly lower（ P 〈0. 05）. FBS,PBG,HbA1c change of the control group had no significant difference（ P 〉0. 05）. After treatment observation group had significant difference in FBS and HbA1c compared with control group（ P 〈0. 05）. The PBG was similar between the two groups. There was no significant difference（ P 〉0. 05）. Two groups of pa-tients,the differences of before and after treatment the TC,TG,LDL-C and HDL-C were significant（ P 〈0. 05）. After treatment,TC,TG and LDL in the observation group was reduced by 10. 41%,17. 92% and 12. 98%,respectively. The TC,TG and LDL-C of the control group reduced by 9. 94%,15. 97% and 13. 46%,respectively. Comparing the differences between groups,there was no statistical significance（ P 〉0. 05）. But HDL-C of the observation group raised by 9. 12%. The HDL-C of the control group raised by 6. 31%. The observation group was significantly higher than the control group. Difference between groups was statistically significant（ P 〈0. 05）. In observation group,the inci-dence of adverse reactions was 3. 77%. The incidence of control group was 7. 55%. By comparing differences,there was no statistical significance （ P 〉0. 05）. Conclusion Pitavastatin can increase high-density lipoprotein cholesterol levels,but also reduce and control of fasting blood glu-cose fluctuations in blood sugar levels than atorvastatin. It is a safe and effective treatment for diabetes,hypercholesterolemia drug,worthy of wider application.