胃癌患者血浆D-二聚体检测的临床意义

目的探讨胃癌患者血浆D-二聚体检测的临床意义。方法回顾性分析80例首诊胃癌患者的病历,从中提取出患者就诊时的D-二聚体水平和临床特征等信息。比较胃癌患者与80例健康个体的血浆D-二聚体水平,分析血浆D-二聚体水平与患者临床特征的关系。结果胃癌患者血浆D-二聚体水平较健康个体增高(P0.01)且其水平随患者原发肿瘤浸润深度、淋巴结转移等级的递进而增加(P0.01)。发生远处转移的患者血浆D-二聚体水平较未发生转移的患者增高(P0.01)。D-二聚体与肿瘤大小、癌抗原72-4呈正相关(P0.01)。肿瘤病理类型与血浆D-二聚体水平无关。结论胃癌患者凝血系统和纤溶系统均处于活化状态。D-二聚体是潜在的胃癌预后标记物。

Measurement of plasma D - dimer in gastric cancer patients and its clinical significance.

Objective To investigate the clinical significance of plasma D - dimer measurement in patients with gastric cancer. Methods The medical records of 80 cases of newly diagnosed gastric cancer patients were retrospectively reviewed, and the plasma D - dimer level and clinical characteristics on admission were collected. The D - dimer level in gastric cancer patients was compared with that in 80 healthy individuals. The correlation between D - dimer and the clinical characteristics was analyzed. Results Gastric cancer patients had higher D - dimer level than healthy individuals （ P 〈 0.01 ）, and D - dimer level was increased as the progress of invasion depth and lymph node metastasis of gastric cancer （ P 〈0.01 for all）. The patients with distant metastasis had increased D - dimer level than those without distant metastasis （ P 〈0.01 ）. D - dimer level was positively correlated with tumor size and CA72 -4 level （ P 〈 0.01 for all）. Conclusion The coagulation and fibrinolysis systems in gastric patients are over - activated. D - dimer is a potential prognostic factor for gastric cancer.