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| 哺乳期避孕药ST-1435衍生物的合成 | |
| 引用本文： | 陈国华,屠树滋,廖清江. 哺乳期避孕药ST-1435衍生物的合成[J]. 药学学报, 1991, 26(8): 615-618 |
| 作者姓名： | 陈国华 屠树滋 廖清江 |
| 作者单位： | 中国药科大学计划生育药物研究中心，中国药科大学计划生育药物研究中心，中国药科大学计划生育药物研究中心 南京 210009，南京 210009，南京 210009 |
| 摘 要： | 19-失碳-16-亚甲基-17α-乙酰氧基黄体酮(3)最早由我国合成,后来西德E.Merk AG药厂使其开发成高效低毒的非口服避孕药,称ST-1435,其皮下埋植缓释系统国外已临床使用,有效避孕期约一年,临床研究还发现它对脂代谢、糖代谢、内分泌与肝功能等均无不良影响,并因其口服无效,近年来国外认为它更适合于哺乳期妇女使用。 |
| 关 键 词： | ST-1435 孕激素受体 哺乳期 避孕药 |
| 收稿时间： | 1990-06-13 |
SYNTHESIS OF ST-1435 DERIVATIVES AS CONTRACEPTIVE FOR LACTATING WOMEN |
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| GH Chen,SZ Tu and QJ Liao. SYNTHESIS OF ST-1435 DERIVATIVES AS CONTRACEPTIVE FOR LACTATING WOMEN[J]. Acta pharmaceutica Sinica, 1991, 26(8): 615-618 | |
| Authors: | GH Chen SZ Tu QJ Liao |
| Affiliation: | Research Center for Drugs of Family Planning, China Pharmaceutical University, Nanjing. |
| Abstract: | Four new ST-1435 derivatives 4-7 were synthesized. Both 4 and 5 are mixture of Z- and E-isomers. 4 was separated into Z- and E-isomers by spinning TLC. Their binding ability to progesterone receptor was examined and found to be less than ST-1435. |
| Keywords: | ST- 1435 Progesterone receptor Lactation Contraceptive |
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