加味四君子汤联合拉米夫定治疗慢性乙型肝炎疗效观察

目的:观察加味四君子汤联合拉米夫定治疗慢性乙型肝炎的疗效。方法:治疗组采用加味四君子汤联合拉米夫定治疗,拉米夫定每天1次,每次100mg;加味四君子汤每天2次,每次150mL,每周连续服用6d,暂停1d,疗程1年。对照组单用拉米夫定100mg,每天1次,疗程1年。结果:治疗组总有效率为90.0%,对照组为70.0%,两组比较有显著性意义;治疗组在HBeAg转阴、HBV-DNA转阴及ALT、AST、TBil复常等方面均优于对照组。结论:加味四君子汤联合拉米夫定治疗慢性乙型肝炎可提高疗效,起协同作用。

Observation on Chronic Hepatitis B Treated by Jiawei Sijunzi Decoction and Lamivadine

Objective：To explore the therapeutic effects of patients with Chronic hepatitis B（CHB） treated by Jiawei Sijunzi decoction and lamivudine.Methods：The treatment group was treated by Jiawei Sijunzi decoction and lamivudine for one year.Jiawei Sijunzi decoction 150mL,twice one day,in consecutive six days a week,suspension one day.lamivudine 100mg,once a day.The control group was treated only by lamivudine 100mg,once a day for one year.Results：The total effective rates were 90.0% in the treatment group and 70.0% in the control group.Significant difference was found between the two groups.The rations of recovery for liver functions（ALT、 AST、TBil）,the sero-conversion rate of HBV-DNA and HBeAg seroconversion rates in the treatment group were betterthan in the control group.Conclusion：Jiawei Sijunzi decoction which play synergies can improve the efficacy of lamivudine in CHB cases.