| 先天性巨结肠一氧化氮的组织化学观察 |
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| 引用本文： | 夏谷良,王果,翁一珍,曹福元,茹立强.先天性巨结肠一氧化氮的组织化学观察[J].中华小儿外科杂志,1995(5). |
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| 作者姓名： | 夏谷良 王果 翁一珍 曹福元 茹立强 |
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| 作者单位： | 同济医科大学附属同济医院小儿外科，同济医科大学神经生物学教研室 |
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| 摘 要： | 采用ＮＡＤＰＨ二磷酸酶组织化学方法，研究先天性巨结肠症ＮＡＮＣ抑制性神经系统。结果提示狭窄段肠管缺乏ＮＯＳ阳性神经丛，肌层内有散在神经纤维，有时可见到粗纤维或小神经干；正常结肠和巨结肠正常段富含阳性神经节细胞和神经纤维。提示ＮＯ与先天性巨结肠发病机理有关。
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| 关 键 词： | 一氧化氮，巨结肠．先天性 |
Preliminary Observations on Nitric Oxide Synthase Histochemistry of Hirschsprung Disease |
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| Xia Guliang,Wang Guo,Weng Yizhen,et al..Preliminary Observations on Nitric Oxide Synthase Histochemistry of Hirschsprung Disease[J].Chinese Journal of Pediatric Surgery,1995(5). |
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| Authors: | Xia Guliang Wang Guo Weng Yizhen |
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| Abstract: | The nitric oxide synthase(NOS)distribution in the enteric nervous system(NANC inhibition system)was studied by NADPH-diphorase histochemistry method.It revealed completely lack of NOS activity in the neuroplexus and in musculature of aganglionic segment,on the other hand in the ganglionic segment,NOS was abundant in pattern similar to normal colon.It suggests that NO has been involved in the pathophysiology of Hirschsprung disease. |
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| Keywords: | Nitric Oxide Megacolon congenital |
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