脐血NSE、TNF-α与VEGF测定早期预测脑性瘫痪高危儿

目的:探讨脐血NSE、TNF-α与VEGF水平对脑瘫高危儿的早期预测价值。方法:研究对象分为3组:早产儿+高危因素组(1组)、足月儿+高危因素组(2组)与正常足月儿组(3组)。应用酶联免疫吸附法检测脐血NSE、TNF-α与VEGF水平。3个组均随访至3岁(死亡及诊断为脑瘫者终止)。结果:与3组相比较,1组与2组NSE、TNF-α与VEGF水平明显增高(P0.05)。至随访结束发现脑性瘫痪患儿9例(10.0%),其中1组为7例(25.9%),2组为2例,3组未发现脑瘫患儿。脑瘫组与非脑瘫组相比较,脑瘫组NSE、TNF-α与VEGF水平明显增高(P0.05)。结论:脐血NSE、TNF-α与VEGF水平测定可以辅助早期预测脑瘫高危儿。

Prognostic value of NSE, TNF - αand VEGF detection in umbilical cord serum in infants with high risk factors of cerebral palsy

Objective:To explore the prognostic value of neuronspecific enolase (NSE),tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) detection in umbilical cord serum in infants with high risk factors of cerebral palsy.Methods:All the study objects were divided into three groups:premature infants with high risk factors group (group 1),term infants with high risk factors group (group 2) and normal term infants (group 3).The serum levels of NSE,TNF-α and VEGF were detected by ELISA.All the infants were followed up until 3 years old (or finished being diagnosed as cerebral palsy or death).Results:The serum levels of NSE,TNF-α and VEGF in group 1 and group 2 were significantly higher than those in group 3 (P<0.05).9 infants (10.0%) were diagnosed as cerebral palsy,including 7 infants (25.9%) in group 1 and 2 infants in group 2.The serum levels of NSE,TNF-α and VEGF in infants with cerebral palsy were significantly higher than those without cerebral palsy (P<0.05).Conclusion:NSE,TNF-α and VEGF detection can assist early prognosis of infants with high risk factors of cerebral palsy.