| 桃核承气汤及其拆方组对蓄血症大鼠模型“瘀热”相关指标的影响 |
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| 引用本文： | 陈光晖,陈子珺,陈德兴. 桃核承气汤及其拆方组对蓄血症大鼠模型“瘀热”相关指标的影响[J]. 中国实验方剂学杂志, 2012, 18(21): 282-286 |
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| 作者姓名： | 陈光晖 陈子珺 陈德兴 |
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| 作者单位： | 上海中医药大学,上海,201203 |
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| 基金项目： | 上海市博士学位点建设科研项目(2011bs1002) |
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| 摘 要： | ![]()
目的:观察桃核承气汤及其拆方组对蓄血症大鼠模型"瘀热"相关指标的影响。方法:间隔24 h两次大鼠尾静脉注射内毒素脂多糖(lipopolysaccharide,LPS)50μg.kg-1造模。第1次尾静脉注射后0.5,12 h,第2次尾静脉注射后0.5 h灌胃给药。给药组剂量全方组10 g.kg-1,调胃组5.7 g.kg-1,调桃组8.6 g.kg-1,调桂组7.1 g.kg-1,桃桂组4.3 g.kg-1。模型对照组,空白对照组给相应剂量生理盐水。末次注射后2 h取血,检测血清中组织纤溶酶原激活物(tissue type plasminogenactivator,t-PA),纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor,PAI-1),超氧化物歧化酶(superoxide dismutase,SOD),丙二醛(malondialdehyde,MDA),一氧化氮(nitric oxide,NO)及血浆中内皮素-1(endothelin-1,ET-1),6-酮-前列腺素-1α(6-keto-prostaglandin F1α,6-keto-F1α),血栓烷素B2(thromboxane B2,TXB2)。结果:全方组,调胃组,调桂组,调桃组能上调SOD(P<0.01),下调MDA(P<0.01)。全方组,调胃组,调桂组能下调PAI-1及t-PA/PAI-1(P<0.01)。调胃组,调桂组还能上调t-PA(P<0.01)。桃桂组对SOD,MDA及PAI-1干预作用小,与全方组比较有差异(P<0.01)。各给药组均能升高大鼠血浆中TXB2,降低6-Keto-PGF1α/TXB2,降低NO。结论:桃核承气汤对"瘀热"指标均有积极的干预作用。各拆方组中,调胃组处于核心地位,对"瘀热"指标作用均比较好。调桂组对反映"瘀"的指标干预作用好于全方组。桃桂组在调解"瘀热"指标中表现均最差。
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| 关 键 词： | 桃核承气汤 拆方组 蓄血症 |
| 收稿时间： | 2012-03-19 |
Experimental Study of Taohe Chengqi Decoction and its Decomposed Recipes on Rat Model with Heat and Blood Stasis Syndrome |
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| CHEN Guang-hui,CHEN Zi-jun and CHEN De-xing. Experimental Study of Taohe Chengqi Decoction and its Decomposed Recipes on Rat Model with Heat and Blood Stasis Syndrome[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(21): 282-286 |
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| Authors: | CHEN Guang-hui CHEN Zi-jun CHEN De-xing |
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| Affiliation: | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | ![]()
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| Keywords: | Taohe Chengqi decoction decomposed recipes heat and blood stasis syndrome |
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